Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells

Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin‐related force remodeling and play an important role in nuclear configuration and force‐sensing mechanotransduction of stem cells. However, further exploration of the interaction between actinin complex and myosin, kin...

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Vydáno v:Advanced science Ročník 12; číslo 14; s. e2416482 - n/a
Hlavní autoři: Wang, Nana, Hou, Yan, Lin, Lili, Xu, Shihui, Lee, Kyubae, Yang, Yingjun, Chen, Yazhou, Li, Yachun, Wang, Xiuhui, Wang, Yongtao, Chen, Tao
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany John Wiley & Sons, Inc 01.04.2025
John Wiley and Sons Inc
Wiley
Témata:
advanced microarrays
Animals
Cell adhesion & migration
Cell Adhesion - physiology
Cell Nucleus - metabolism
Cytoskeleton
Cytoskeleton - metabolism
Design
force‐sensing mechanotransduction
heterogeneous focal adhesion
Humans
Interdisciplinary subjects
Mechanical properties
mechanical remodeling
Mechanics
Mechanotransduction, Cellular - physiology
Medical diagnosis
Morphogenesis
Morphology
nuclear configuration
Silicon wafers
Stem cells
Stem Cells - cytology
Stem Cells - metabolism
Stem Cells - physiology
Viscosity
heterogeneous focal adhesion
advanced microarrays
mechanical remodeling
force‐sensing mechanotransduction
nuclear configuration
ISSN:2198-3844, 2198-3844
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Shrnutí:Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin‐related force remodeling and play an important role in nuclear configuration and force‐sensing mechanotransduction of stem cells. However, further exploration of the interaction between actinin complex and myosin, kinetics, and molecular mechanism of cytoskeleton structures to nucleate within the engineered stem cells is vague. An extensive comprehension of cell morphogenesis, force remodeling, and nuclear force‐sensing mechanotransduction is essential to reveal the basic physical principles of cytoskeleton polymerization and force‐related signaling delivery. Advanced microarrays are designed to determine heterogeneous cell morphology and cell adhesion behaviors in stem cells. The heterogeneity from the engineered microarrays is transferred into nuclei to regulate nuclear configuration and force‐sensing mechanotransduction by the evaluation of Lamins, YAP, and BrdU expression. Tuning the activation of adhesion proteins and cytoskeleton nucleators to adjust heterogeneous cell mechanics may be the underlying mechanism to change nuclear force‐sensing configuration in response to its physiological mechanotransduction in microarrayed stem cells. Engineered microarrays are prepared by the photolithography and further decorated via fibronectin protein to determine the morphogenesis of stem cells. Heterogeneous integrin expression and focal adhesion formation are regulated in microarrayed cells. Polar remodeling of cytoskeleton nanomechanics happens in the heterogeneous cells. Nuclear configuration circulation is explained through force‐sensing mechanotransduction by the evaluation of Lamins, YAP, and BrdU analysis.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Correction added on 18 February 2025, after first online publication: affiliation of author Yongtao Wang is updated.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202416482