Mutational landscape of circulating tumor DNA identifies distinct molecular features associated with therapeutic response in patients with metastatic colorectal cancer

Background: We investigated the mutational landscape of circulating tumor DNA (ctDNA) in predicting tumor response to first-line treatment in patients with metastatic colorectal cancer (mCRC). Methods: We included 41 patients with initially unresectable mCRC, treated with 5-fluorouracil/leucovorin/o...

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Veröffentlicht in:	Therapeutic advances in medical oncology Jg. 14; S. 17588359211070643
Hauptverfasser:	Shi, Min, Yuan, Hong, Ji, Jun, Zhang, Shouwei, Li, Qingyuan, Chen, Yawei, Gong, Xiaoli, Zhu, Zhenggang, Zhang, Jun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London, England SAGE Publications 01.01.2022 Sage Publications Ltd SAGE Publishing
Schlagworte:	5-Fluorouracil Bevacizumab Colorectal cancer Colorectal carcinoma Genomic analysis Irinotecan Metastases Metastasis Monoclonal antibodies Mutation Next-generation sequencing Original Research Oxaliplatin Patients Survival Tumors molecular mutational burden metastatic colorectal cancer KRAS prognosis circulating tumor DNA
ISSN:	1758-8359, 1758-8340, 1758-8359
Online-Zugang:	Volltext
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