Regularized siamese neural network for unsupervised outlier detection on brain multiparametric magnetic resonance imaging: Application to epilepsy lesion screening

•We cast the challenging problem of detecting subtle brain lesions as a per voxel outlier detection problem.•Our brain anomaly detection model is trained on normal subjects only.•Our model combines unsupervised latent representation with a novel deep siamese network and one-class classification.•Pat...

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