cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization

RhoA-inhibitory bacterial toxins, such as Staphylococcus aureus EDIN toxin, induce large transendothelial cell macroaperture (TEM) tunnels that rupture the host endothelium barrier and promote bacterial dissemination. Host cells repair these tunnels by extending actin-rich membrane waves from the TE...

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Veröffentlicht in:	Cell host & microbe Jg. 10; H. 5; S. 464
Hauptverfasser:	Maddugoda, Madhavi P, Stefani, Caroline, Gonzalez-Rodriguez, David, Saarikangas, Juha, Torrino, Stéphanie, Janel, Sebastien, Munro, Patrick, Doye, Anne, Prodon, François, Aurrand-Lions, Michel, Goossens, Pierre L, Lafont, Frank, Bassereau, Patricia, Lappalainen, Pekka, Brochard, Françoise, Lemichez, Emmanuel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.11.2011
Schlagworte:	Actin-Related Protein 2-3 Complex - chemistry Actin-Related Protein 2-3 Complex - genetics Actin-Related Protein 2-3 Complex - metabolism Animals Anthrax - metabolism Anthrax - microbiology Antigens, Bacterial - metabolism Bacillus anthracis - genetics Bacillus anthracis - metabolism Bacterial Toxins - metabolism Cyclic AMP - metabolism Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - microbiology Humans Mice Mice, Inbred BALB C Microfilament Proteins - genetics Microfilament Proteins - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Polymerization Signal Transduction
ISSN:	1934-6069, 1934-6069
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