The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes

Two neutralizing human mAbs, 2F5 and 4E10, that react with the HIV-1 envelope gp41 membrane proximal region are also polyspecific autoantibodies that bind to anionic phospholipids. To determine the autoantibody nature of these Abs, we have compared their reactivities with human anti-cardiolipin mAbs...

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Bibliographic Details
Published in:	Journal of Immunology Vol. 178; no. 7; pp. 4424 - 4435
Main Authors:	Alam, S Munir, McAdams, Mildred, Boren, David, Rak, Michael, Scearce, Richard M, Gao, Feng, Camacho, Zenaido T, Gewirth, Daniel, Kelsoe, Garnett, Chen, Pojen, Haynes, Barton F
Format:	Journal Article
Language:	English
Published:	England 01.04.2007
Subjects:	Amino Acid Sequence Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibody Specificity Antiphospholipid Syndrome - immunology Autoantibodies - immunology Cardiolipins - immunology HIV Antibodies - immunology HIV Envelope Protein gp41 - immunology HIV-1 - immunology Human immunodeficiency virus 1 Humans Lipids - immunology Liposomes - chemistry Mice Molecular Sequence Data
ISSN:	0022-1767, 1365-2567
Online Access:	Get full text
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