Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1

Although maternal-fetal cholesterol transfer may serve to compensate for insufficient fetal cholesterol biosynthesis under pathological conditions, it may have detrimental consequences under conditions of maternal hypercholesterolemia leading to preatherosclerotic lesion development in fetal aortas....

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Veröffentlicht in:	Circulation research Jg. 104; H. 5; S. 600
Hauptverfasser:	Stefulj, Jasminka, Panzenboeck, Ute, Becker, Tatjana, Hirschmugl, Birgit, Schweinzer, Cornelia, Lang, Ingrid, Marsche, Gunther, Sadjak, Anton, Lang, Uwe, Desoye, Gernot, Wadsack, Christian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 13.03.2009
Schlagworte:	Apolipoprotein A-I - metabolism ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Subfamily G ATP Binding Cassette Transporter, Subfamily G, Member 1 ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Cell Membrane - metabolism Cells, Cultured Cholesterol - metabolism DNA-Binding Proteins - metabolism Endothelial Cells - drug effects Endothelial Cells - metabolism Female Glyburide - pharmacology Humans Lipoproteins, HDL3 - metabolism Liver X Receptors Maternal-Fetal Exchange Orphan Nuclear Receptors Placenta - blood supply Pregnancy Probucol - pharmacology Receptors, Cytoplasmic and Nuclear - metabolism RNA Interference RNA, Small Interfering - metabolism Scavenger Receptors, Class B - metabolism Time Factors
ISSN:	1524-4571, 1524-4571
Online-Zugang:	Weitere Angaben
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