Identification of tight junction modulating lipids

Tight junctions (TJs) play an important role in regulating paracellular drug transport. The aim of this study was to identify lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) and/or TJ permeability in epithelial tissue. In this study, we developed a screen for ide...

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Vydané v:	Journal of pharmaceutical sciences Ročník 98; číslo 2; s. 606
Hlavní autori:	Chen-Quay, Shu-Chih, Eiting, Kristine T, Li, Angela W-A, Lamharzi, Najib, Quay, Steven C
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.02.2009
Predmet:	Cell Survival - drug effects Cells, Cultured Dextrans - metabolism Dose-Response Relationship, Drug Drug Carriers Electric Impedance Epithelial Cells - drug effects Epithelial Cells - metabolism Ethers - pharmacology Excipients - pharmacology Excipients - toxicity Fluoresceins - metabolism Fluorescent Antibody Technique Glycosides - pharmacology Humans Membrane Lipids - metabolism Membrane Lipids - pharmacology Membrane Lipids - toxicity Oxidation-Reduction Permeability Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Sphingosine - pharmacology Tight Junctions - drug effects Tight Junctions - metabolism
ISSN:	1520-6017, 1520-6017
On-line prístup:	Zistit podrobnosti o prístupe
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