Identification of tight junction modulating lipids

Tight junctions (TJs) play an important role in regulating paracellular drug transport. The aim of this study was to identify lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) and/or TJ permeability in epithelial tissue. In this study, we developed a screen for ide...

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Bibliographic Details
Published in:	Journal of pharmaceutical sciences Vol. 98; no. 2; p. 606
Main Authors:	Chen-Quay, Shu-Chih, Eiting, Kristine T, Li, Angela W-A, Lamharzi, Najib, Quay, Steven C
Format:	Journal Article
Language:	English
Published:	United States 01.02.2009
Subjects:	Cell Survival - drug effects Cells, Cultured Dextrans - metabolism Dose-Response Relationship, Drug Drug Carriers Electric Impedance Epithelial Cells - drug effects Epithelial Cells - metabolism Ethers - pharmacology Excipients - pharmacology Excipients - toxicity Fluoresceins - metabolism Fluorescent Antibody Technique Glycosides - pharmacology Humans Membrane Lipids - metabolism Membrane Lipids - pharmacology Membrane Lipids - toxicity Oxidation-Reduction Permeability Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Sphingosine - pharmacology Tight Junctions - drug effects Tight Junctions - metabolism
ISSN:	1520-6017, 1520-6017
Online Access:	Get more information
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