The Intestinal Microbiota and Colorectal Cancer

The intestinal microbiota, composed of a large population of microorganisms, is often considered a “forgotten organ” in human health and diseases. Increasing evidence indicates that dysbiosis of the intestinal microbiota is closely related to colorectal cancer (CRC). The roles for intestinal microor...

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Vydané v:Frontiers in immunology Ročník 11; s. 615056
Hlavní autori: Cheng, Yiwen, Ling, Zongxin, Li, Lanjuan
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Media S.A 30.11.2020
Predmet:
biomarker
colorectal cancer
dietary intervention
Immunology
inflammation
intestinal microbiota
metabolites
intestinal microbiota
colorectal cancer
biomarker
inflammation
metabolites
dietary intervention
ISSN:1664-3224, 1664-3224
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Shrnutí:The intestinal microbiota, composed of a large population of microorganisms, is often considered a “forgotten organ” in human health and diseases. Increasing evidence indicates that dysbiosis of the intestinal microbiota is closely related to colorectal cancer (CRC). The roles for intestinal microorganisms that initiated and facilitated the CRC process are becoming increasingly clear. Hypothesis models have been proposed to illustrate the complex relationship between the intestinal microbiota and CRC. Recent studies have identified Streptococcus bovis , enterotoxigenic Bacteroides fragilis , Fusobacterium nucleatum , Enterococcus faecalis , Escherichia coli , and Peptostreptococcus anaerobius as CRC candidate pathogens. In this review, we summarized the mechanisms involved in microbiota-related colorectal carcinogenesis, including inflammation, pathogenic bacteria, and their virulence factors, genotoxins, oxidative stress, bacterial metabolites, and biofilm. We also described the clinical values of intestinal microbiota and novel strategies for preventing and treating CRC.
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SourceType-Scholarly Journals-1
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ObjectType-Review-3
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Edited by: Qixiao Zhai, Jiangnan University, China
Reviewed by: Zhihong Liu, Guangdong Academy of Science, China; Weiling Li, Dalian Medical University, China
This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.615056