The microbiota-gut-brain axis and neurodevelopmental disorders

The gut microbiota has been found to interact with the brain through the microbiota-gut-brain axis, regulating various physiological processes. In recent years, the impacts of the gut microbiota on neurodevelopment through this axis have been increasingly appreciated. The gut microbiota is commonly...

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Veröffentlicht in:	Protein & cell Jg. 14; H. 10; S. 762 - 775
Hauptverfasser:	Wang, Qinwen, Yang, Qianyue, Liu, Xingyin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Germany Higher Education Press 25.10.2023 Springer Nature B.V Oxford University Press
Schlagworte:	Attention deficit hyperactivity disorder Autism Autism Spectrum Disorder - metabolism Bacteria Brain - metabolism brain axis Brain research Brain-Gut Axis Fatty acids Feces Gastrointestinal Microbiome gut gut microbiome Gut microbiota Gut-brain axis Hospitals Humans Immunology Intestinal microflora Metabolites Microbiota Neurodevelopment Neurodevelopmental disorders Neurodevelopmental Disorders - metabolism Pathogens Physiology Rett syndrome Reviews microbiota gut microbiome neurodevelopmental disorders brain axis gut
ISSN:	1674-800X, 1674-8018, 1674-8018
Online-Zugang:	Volltext
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Zusammenfassung:	The gut microbiota has been found to interact with the brain through the microbiota-gut-brain axis, regulating various physiological processes. In recent years, the impacts of the gut microbiota on neurodevelopment through this axis have been increasingly appreciated. The gut microbiota is commonly considered to regulate neurodevelopment through three pathways, the immune pathway, the neuronal pathway, and the endocrine/systemic pathway, with overlaps and crosstalks in between. Accumulating studies have identified the role of the microbiota-gut-brain axis in neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, and Rett Syndrome. Numerous researchers have examined the physiological and pathophysiological mechanisms influenced by the gut microbiota in neurodevelopmental disorders (NDDs). This review aims to provide a comprehensive overview of advancements in research pertaining to the microbiota-gut-brain axis in NDDs. Furthermore, we analyzed both the current state of research progress and discuss future perspectives in this field.
Bibliographie:	microbiota gut microbiome Document accepted on :2023-04-27 gut brain axis Document received on :2023-03-26 neurodevelopmental disorders ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Qinwen Wang and Qianyue Yang contributed equally to this work.
ISSN:	1674-800X 1674-8018 1674-8018
DOI:	10.1093/procel/pwad026