Cysteine cathepsins and extracellular matrix degradation

Cysteine cathepsins are normally found in the lysosomes where they are involved in intracellular protein turnover. Their ability to degrade the components of the extracellular matrix in vitro was first reported more than 25years ago. However, cathepsins were for a long time not considered to be amon...

Full description

Saved in:

Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1840; no. 8; pp. 2560 - 2570
Main Authors:	Fonović, Marko, Turk, Boris
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.08.2014
Subjects:	acidification Animals bone resorption cardiovascular diseases Cathepsin cathepsin K Cathepsins - chemistry Cathepsins - metabolism Collagen cysteine Cysteine - metabolism drugs elastin Extracellular matrix Extracellular Matrix - metabolism Glycosaminoglycan Humans Lysosome lysosomes Molecular Targeted Therapy neoplasms Osteoporosis protein metabolism secretion Substrate Specificity Osteoporosis Extracellular matrix Glycosaminoglycan Cathepsin Collagen Lysosome
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!