The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

We and others have previously identified a loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts (CAFs) as a powerful single independent predictor of breast cancer patient tumor recurrence, metastasis, tamoxifen-resistance, and poor clinical outcome. However, it remains unknown how los...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 9; no. 10; pp. 1960 - 1971
Main Authors:	Bonuccelli, Gloria, Whitaker-Menezes, Diana, Castello-Cros, Remedios, Pavlides, Stephanos, Pestell, Richard G., Fatatis, Alessandro, Witkiewicz, Agnieszka K., Vander Heiden, Matthew G., Migneco, Gemma, Chiavarina, Barbara, Frank, Philippe G., Capozza, Franco, Flomenberg, Neal, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 15.05.2010
Subjects:	Animals Binding Biology Bioscience Blotting, Western Calcium Cancer Caveolin 1 - deficiency Caveolin 1 - genetics Cell Cell Line, Tumor Culture Media, Conditioned Cycle Deoxyglucose - pharmacology Dichloroacetic Acid - pharmacology Electrophoresis, Gel, Two-Dimensional Electrophoresis, Polyacrylamide Gel Fibroblasts - cytology Fibroblasts - metabolism Glycolysis - drug effects Humans Immunohistochemistry Lactate Dehydrogenases - genetics Lactate Dehydrogenases - metabolism Landes Mice Mice, Nude Microscopy, Fluorescence Organogenesis Proteins Proteomics Pyruvate Kinase - genetics Pyruvate Kinase - metabolism Xenograft Model Antitumor Assays
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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