Periodontitis and arterial stiffness: a systematic review and meta-analysis
Introduction and Aims Patients with periodontitis have a higher risk of cardiovascular diseases, although a causal relationship between these conditions remains unclear. Arterial stiffness is considered a marker of arteriosclerosis and a risk factor for cardiovascular diseases. A systematic review o...
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| Vydané v: | Journal of clinical periodontology Ročník 42; číslo 11; s. 977 - 987 |
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| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
Blackwell Publishing Ltd
01.11.2015
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| Predmet: | |
| ISSN: | 0303-6979, 1600-051X |
| On-line prístup: | Získať plný text |
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| Shrnutí: | Introduction and Aims
Patients with periodontitis have a higher risk of cardiovascular diseases, although a causal relationship between these conditions remains unclear. Arterial stiffness is considered a marker of arteriosclerosis and a risk factor for cardiovascular diseases. A systematic review of the literature on clinical studies using pulse wave velocity (PWV) to assess arterial stiffness in patients with periodontitis was carried out to answer the following questions: (i) Do patients with periodontitis have impaired arterial stiffness compared to non‐periodontal diseased subjects? (ii) Is periodontal treatment effective as a means to improve arterial stiffness in patients with periodontitis?
Literature Review
Literature search was done on different databases up to September 2014. All clinical studies (excluding case reports) using PWV in patients with periodontitis were retrieved for a full‐text evaluation. A total of 10 studies were included. Patients with periodontitis have increased arterial stiffness compared to controls (PWV mean difference 0.85 m/s; 95% confidence interval: 0.53–1.16; p<0.00001). The only two interventional studies showed contradictory results on the effects of periodontal treatment on PWV.
Conclusion
Patients with periodontitis appear to have higher values of PWV compared to controls. The effect of periodontal treatment on arterial stiffness remains unclear. |
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| Bibliografia: | Table S1. Papers excluded for clearly not fulfilling the inclusion criteria (n = 21). Table S2. Risk of bias for randomized clinical trials based on the Cochrane Handbook for Systematic Reviews of Interventions. Table S3. Risk of bias for non-randomized clinical trials, cohort studies, case-series based on the Newcastle-Ottawa Scale. ark:/67375/WNG-75Q04MDF-W ArticleID:JCPE12467 istex:34B26EFFE6501582948915B512C6EF62259C25DF The authors have no conflict of interest to disclose. No external funding, apart from the support of the authors' institution, was available for this study. Conflict of interest and source of funding statement ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Review-1 ObjectType-Article-3 ObjectType-Undefined-4 |
| ISSN: | 0303-6979 1600-051X |
| DOI: | 10.1111/jcpe.12467 |