Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma

Histone deacetylases (HDAC) control gene expression through their ability to acetylate proteins, thereby influencing a diverse range of cellular functions. Class I HDAC (HDAC1-3 and 8) and HDAC6 are predominantly upregulated in malignancies and their altered expression in some cancers has a signific...

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Bibliographic Details
Published in:	Epigenetics Vol. 9; no. 11; pp. 1511 - 1520
Main Authors:	Mithraprabhu, Sridurga, Kalff, Anna, Chow, Annie, Khong, Tiffany, Spencer, Andrew
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 02.11.2014
Subjects:	Cell Line, Tumor Class I HDAC Disease-Free Survival Gene Expression Regulation, Neoplastic HDAC expression hematological malignancy Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histone Deacetylase 6 histone deacetylases Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Immunohistochemistry multiple myeloma Multiple Myeloma - enzymology Multiple Myeloma - genetics Multiple Myeloma - mortality Predictive Value of Tests Prognosis Reference Values Research Paper multiple myeloma histone deacetylases hematological malignancy Class I HDAC prognosis HDAC expression
ISSN:	1559-2294, 1559-2308, 1559-2308
Online Access:	Get full text
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