Effect of intrahippocampal microinjection of VU0155041, a positive allosteric modulator of mGluR4, on long term potentiation in a valproic acid-induced autistic male rat model

The precise cause of autism spectrum disorder (ASD) is not fully understood. Despite the involvement of glutamatergic dysregulation in autism, the specific contribution of mGlu4 receptors to synaptic plasticity remains unclear. Using the positive allosteric modulator VU0155041, we aimed to restore l...

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Vydané v:IBRO neuroscience reports Ročník 16; s. 629 - 634
Hlavní autori: Ebrahimi, Zahra, Gholipour, Parsa, Mohammadkhani, Reihaneh, Ghahremani, Reza, Sarihi, Abdolrahman, Komaki, Alireza, Salehi, Iraj, Karimi, Seyed Asaad
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier Inc 01.06.2024
Elsevier
Predmet:
Autism Spectrum Disorder
Long-term potentiation
MGlu4 receptors
Research Paper
Valproic acid
VU0155041
VU0155041
Autism Spectrum Disorder
Valproic acid
MGlu4 receptors
Long-term potentiation
ISSN:2667-2421, 2667-2421
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Shrnutí:The precise cause of autism spectrum disorder (ASD) is not fully understood. Despite the involvement of glutamatergic dysregulation in autism, the specific contribution of mGlu4 receptors to synaptic plasticity remains unclear. Using the positive allosteric modulator VU0155041, we aimed to restore long-term potentiation (LTP) in the perforant path-dentate gyrus (PP-DG) pathway in VPA-induced autistic rat model. High-frequency stimulation was applied to the PP-DG synapse to induce LTP, while the VU0155041 was administered into the DG. Unexpectedly, VU0155041 failed to alleviate the observed LTP reduction in VPA-exposed rats, further resulting in a significant decrease in population spike LTP. This unexpected outcome prompts discussion on the complex nature of mGlu4 receptor modulation, highlighting potential interference with physiological processes underlying synaptic plasticity.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:2667-2421
2667-2421
DOI:10.1016/j.ibneur.2024.05.005