Host phylogeny constrains cross-species emergence and establishment of rabies virus in bats

For RNA viruses, rapid viral evolution and the biological similarity of closely related host species have been proposed as key determinants of the occurrence and long-term outcome of cross-species transmission. Using a data set of hundreds of rabies viruses sampled from 23 North American bat species...

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Published in:	Science (American Association for the Advancement of Science) Vol. 329; no. 5992; p. 676
Main Authors:	Streicker, Daniel G, Turmelle, Amy S, Vonhof, Maarten J, Kuzmin, Ivan V, McCracken, Gary F, Rupprecht, Charles E
Format:	Journal Article
Language:	English
Published:	United States 06.08.2010
Subjects:	Animals Bayes Theorem Chiroptera - classification Chiroptera - genetics Chiroptera - virology Communicable Diseases, Emerging - transmission Communicable Diseases, Emerging - veterinary Communicable Diseases, Emerging - virology Evolution, Molecular Genes, Viral Host-Pathogen Interactions Likelihood Functions Molecular Sequence Data Monte Carlo Method Nucleocapsid Proteins - genetics Phylogeny Rabies - transmission Rabies - veterinary Rabies - virology Rabies virus - classification Rabies virus - genetics Rabies virus - pathogenicity Rabies virus - physiology Species Specificity
ISSN:	1095-9203, 1095-9203
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Abstract	For RNA viruses, rapid viral evolution and the biological similarity of closely related host species have been proposed as key determinants of the occurrence and long-term outcome of cross-species transmission. Using a data set of hundreds of rabies viruses sampled from 23 North American bat species, we present a general framework to quantify per capita rates of cross-species transmission and reconstruct historical patterns of viral establishment in new host species using molecular sequence data. These estimates demonstrate diminishing frequencies of both cross-species transmission and host shifts with increasing phylogenetic distance between bat species. Evolutionary constraints on viral host range indicate that host species barriers may trump the intrinsic mutability of RNA viruses in determining the fate of emerging host-virus interactions.
AbstractList	For RNA viruses, rapid viral evolution and the biological similarity of closely related host species have been proposed as key determinants of the occurrence and long-term outcome of cross-species transmission. Using a data set of hundreds of rabies viruses sampled from 23 North American bat species, we present a general framework to quantify per capita rates of cross-species transmission and reconstruct historical patterns of viral establishment in new host species using molecular sequence data. These estimates demonstrate diminishing frequencies of both cross-species transmission and host shifts with increasing phylogenetic distance between bat species. Evolutionary constraints on viral host range indicate that host species barriers may trump the intrinsic mutability of RNA viruses in determining the fate of emerging host-virus interactions.For RNA viruses, rapid viral evolution and the biological similarity of closely related host species have been proposed as key determinants of the occurrence and long-term outcome of cross-species transmission. Using a data set of hundreds of rabies viruses sampled from 23 North American bat species, we present a general framework to quantify per capita rates of cross-species transmission and reconstruct historical patterns of viral establishment in new host species using molecular sequence data. These estimates demonstrate diminishing frequencies of both cross-species transmission and host shifts with increasing phylogenetic distance between bat species. Evolutionary constraints on viral host range indicate that host species barriers may trump the intrinsic mutability of RNA viruses in determining the fate of emerging host-virus interactions. For RNA viruses, rapid viral evolution and the biological similarity of closely related host species have been proposed as key determinants of the occurrence and long-term outcome of cross-species transmission. Using a data set of hundreds of rabies viruses sampled from 23 North American bat species, we present a general framework to quantify per capita rates of cross-species transmission and reconstruct historical patterns of viral establishment in new host species using molecular sequence data. These estimates demonstrate diminishing frequencies of both cross-species transmission and host shifts with increasing phylogenetic distance between bat species. Evolutionary constraints on viral host range indicate that host species barriers may trump the intrinsic mutability of RNA viruses in determining the fate of emerging host-virus interactions.
Author	Streicker, Daniel G Vonhof, Maarten J Turmelle, Amy S Rupprecht, Charles E McCracken, Gary F Kuzmin, Ivan V
Author_xml	– sequence: 1 givenname: Daniel G surname: Streicker fullname: Streicker, Daniel G email: dstrike@uga.edu organization: Rabies Team, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. dstrike@uga.edu – sequence: 2 givenname: Amy S surname: Turmelle fullname: Turmelle, Amy S – sequence: 3 givenname: Maarten J surname: Vonhof fullname: Vonhof, Maarten J – sequence: 4 givenname: Ivan V surname: Kuzmin fullname: Kuzmin, Ivan V – sequence: 5 givenname: Gary F surname: McCracken fullname: McCracken, Gary F – sequence: 6 givenname: Charles E surname: Rupprecht fullname: Rupprecht, Charles E
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/20689015$$D View this record in MEDLINE/PubMed
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SubjectTerms	Animals Bayes Theorem Chiroptera - classification Chiroptera - genetics Chiroptera - virology Communicable Diseases, Emerging - transmission Communicable Diseases, Emerging - veterinary Communicable Diseases, Emerging - virology Evolution, Molecular Genes, Viral Host-Pathogen Interactions Likelihood Functions Molecular Sequence Data Monte Carlo Method Nucleocapsid Proteins - genetics Phylogeny Rabies - transmission Rabies - veterinary Rabies - virology Rabies virus - classification Rabies virus - genetics Rabies virus - pathogenicity Rabies virus - physiology Species Specificity
Title	Host phylogeny constrains cross-species emergence and establishment of rabies virus in bats
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