Host phylogeny constrains cross-species emergence and establishment of rabies virus in bats

For RNA viruses, rapid viral evolution and the biological similarity of closely related host species have been proposed as key determinants of the occurrence and long-term outcome of cross-species transmission. Using a data set of hundreds of rabies viruses sampled from 23 North American bat species...

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Vydáno v:Science (American Association for the Advancement of Science) Ročník 329; číslo 5992; s. 676
Hlavní autoři: Streicker, Daniel G, Turmelle, Amy S, Vonhof, Maarten J, Kuzmin, Ivan V, McCracken, Gary F, Rupprecht, Charles E
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 06.08.2010
Témata:
Animals
Bayes Theorem
Chiroptera - classification
Chiroptera - genetics
Chiroptera - virology
Communicable Diseases, Emerging - transmission
Communicable Diseases, Emerging - veterinary
Communicable Diseases, Emerging - virology
Evolution, Molecular
Genes, Viral
Host-Pathogen Interactions
Likelihood Functions
Molecular Sequence Data
Monte Carlo Method
Nucleocapsid Proteins - genetics
Phylogeny
Rabies - transmission
Rabies - veterinary
Rabies - virology
Rabies virus - classification
Rabies virus - genetics
Rabies virus - pathogenicity
Rabies virus - physiology
Species Specificity
ISSN:1095-9203, 1095-9203
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Shrnutí:For RNA viruses, rapid viral evolution and the biological similarity of closely related host species have been proposed as key determinants of the occurrence and long-term outcome of cross-species transmission. Using a data set of hundreds of rabies viruses sampled from 23 North American bat species, we present a general framework to quantify per capita rates of cross-species transmission and reconstruct historical patterns of viral establishment in new host species using molecular sequence data. These estimates demonstrate diminishing frequencies of both cross-species transmission and host shifts with increasing phylogenetic distance between bat species. Evolutionary constraints on viral host range indicate that host species barriers may trump the intrinsic mutability of RNA viruses in determining the fate of emerging host-virus interactions.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1095-9203
1095-9203
DOI:10.1126/science.1188836