Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance

Elucidating the mechanisms of resistance to immunotherapy and developing strategies to improve its efficacy are challenging goals. Bioinformatics analysis demonstrates that high CDK6 expression in melanoma is associated with poor progression-free survival of patients receiving single-agent immunothe...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 42; H. 4; S. 112314
Hauptverfasser:	Gao, Xueliang, Wu, Yongxia, Chick, Joel M., Abbott, Andrea, Jiang, Baishan, Wang, David J., Comte-Walters, Susana, Johnson, Roger H., Oberholtzer, Nathaniel, Nishimura, Michael I., Gygi, Steven P., Mehta, Anand, Guttridge, Denis C., Ball, Lauren, Mehrotra, Shikhar, Sicinski, Piotr, Yu, Xue-Zhong, Wang, Haizhen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 25.04.2023 Elsevier
Schlagworte:	CD3ζ CDK6 CP: Cancer CP: Immunology cyclin D3 Cyclin D3 - metabolism Cyclin-Dependent Kinase 4 - metabolism Cyclin-Dependent Kinase 6 - metabolism Humans Immunotherapy Neoplasms Phosphorylation PTP1B Signal Transduction TCPTP Tumor Microenvironment CP: Immunology TCPTP CDK6 PTP1B CP: Cancer cyclin D3 CD3ζ
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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