Surveillance of transmitted HIV-1 drug resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009

Surveillance of human immunodeficiency virus type 1 transmitted drug resistance (TDR) was conducted among pregnant women in South Africa over a 5-year period after the initiation of a large national antiretroviral treatment program. Analysis of TDR data from 9 surveys conducted between 2005 and 2009...

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Vydáno v:	Clinical infectious diseases Ročník 54 Suppl 4; s. S334
Hlavní autoři:	Hunt, G M, Ledwaba, J, Basson, A E, Moyes, J, Cohen, C, Singh, B, Bertagnolio, S, Jordan, M R, Puren, A, Morris, L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.05.2012
Témata:	Adolescent Adult Anti-Retroviral Agents - pharmacology Drug Resistance, Viral Female Genotyping Techniques HIV Infections - epidemiology HIV Infections - transmission HIV Infections - virology HIV-1 - classification HIV-1 - drug effects HIV-1 - genetics Humans Population Surveillance Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - virology Retrospective Studies South Africa - epidemiology South Africa
ISSN:	1537-6591, 1537-6591
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Abstract	Surveillance of human immunodeficiency virus type 1 transmitted drug resistance (TDR) was conducted among pregnant women in South Africa over a 5-year period after the initiation of a large national antiretroviral treatment program. Analysis of TDR data from 9 surveys conducted between 2005 and 2009 in 2 provinces of South Africa suggests that while TDR remains low (<5%) in Gauteng Province, it may be increasing in KwaZulu-Natal, with the most recent survey showing moderate (5%-15%) levels of resistance to the nonnucleoside reverse transcriptase inhibitor drug class.
AbstractList	Surveillance of human immunodeficiency virus type 1 transmitted drug resistance (TDR) was conducted among pregnant women in South Africa over a 5-year period after the initiation of a large national antiretroviral treatment program. Analysis of TDR data from 9 surveys conducted between 2005 and 2009 in 2 provinces of South Africa suggests that while TDR remains low (<5%) in Gauteng Province, it may be increasing in KwaZulu-Natal, with the most recent survey showing moderate (5%-15%) levels of resistance to the nonnucleoside reverse transcriptase inhibitor drug class.Surveillance of human immunodeficiency virus type 1 transmitted drug resistance (TDR) was conducted among pregnant women in South Africa over a 5-year period after the initiation of a large national antiretroviral treatment program. Analysis of TDR data from 9 surveys conducted between 2005 and 2009 in 2 provinces of South Africa suggests that while TDR remains low (<5%) in Gauteng Province, it may be increasing in KwaZulu-Natal, with the most recent survey showing moderate (5%-15%) levels of resistance to the nonnucleoside reverse transcriptase inhibitor drug class. Surveillance of human immunodeficiency virus type 1 transmitted drug resistance (TDR) was conducted among pregnant women in South Africa over a 5-year period after the initiation of a large national antiretroviral treatment program. Analysis of TDR data from 9 surveys conducted between 2005 and 2009 in 2 provinces of South Africa suggests that while TDR remains low (<5%) in Gauteng Province, it may be increasing in KwaZulu-Natal, with the most recent survey showing moderate (5%-15%) levels of resistance to the nonnucleoside reverse transcriptase inhibitor drug class.
Author	Ledwaba, J Singh, B Cohen, C Puren, A Basson, A E Jordan, M R Bertagnolio, S Moyes, J Hunt, G M Morris, L
Author_xml	– sequence: 1 givenname: G M surname: Hunt fullname: Hunt, G M email: gillianh@nicd.ac.za organization: National Institute for Communicable Diseases, Johannesburg, South Africa. gillianh@nicd.ac.za – sequence: 2 givenname: J surname: Ledwaba fullname: Ledwaba, J – sequence: 3 givenname: A E surname: Basson fullname: Basson, A E – sequence: 4 givenname: J surname: Moyes fullname: Moyes, J – sequence: 5 givenname: C surname: Cohen fullname: Cohen, C – sequence: 6 givenname: B surname: Singh fullname: Singh, B – sequence: 7 givenname: S surname: Bertagnolio fullname: Bertagnolio, S – sequence: 8 givenname: M R surname: Jordan fullname: Jordan, M R – sequence: 9 givenname: A surname: Puren fullname: Puren, A – sequence: 10 givenname: L surname: Morris fullname: Morris, L
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SubjectTerms	Adolescent Adult Anti-Retroviral Agents - pharmacology Drug Resistance, Viral Female Genotyping Techniques HIV Infections - epidemiology HIV Infections - transmission HIV Infections - virology HIV-1 - classification HIV-1 - drug effects HIV-1 - genetics Humans Population Surveillance Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - virology Retrospective Studies South Africa - epidemiology
Title	Surveillance of transmitted HIV-1 drug resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009
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