Surveillance of transmitted HIV-1 drug resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009

Surveillance of human immunodeficiency virus type 1 transmitted drug resistance (TDR) was conducted among pregnant women in South Africa over a 5-year period after the initiation of a large national antiretroviral treatment program. Analysis of TDR data from 9 surveys conducted between 2005 and 2009...

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Bibliographic Details
Published in:Clinical infectious diseases Vol. 54 Suppl 4; p. S334
Main Authors: Hunt, G M, Ledwaba, J, Basson, A E, Moyes, J, Cohen, C, Singh, B, Bertagnolio, S, Jordan, M R, Puren, A, Morris, L
Format: Journal Article
Language:English
Published: United States 15.05.2012
Subjects:
Adolescent
Adult
Anti-Retroviral Agents - pharmacology
Drug Resistance, Viral
Female
Genotyping Techniques
HIV Infections - epidemiology
HIV Infections - transmission
HIV Infections - virology
HIV-1 - classification
HIV-1 - drug effects
HIV-1 - genetics
Humans
Population Surveillance
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - virology
Retrospective Studies
South Africa - epidemiology
South Africa
ISSN:1537-6591, 1537-6591
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Summary:Surveillance of human immunodeficiency virus type 1 transmitted drug resistance (TDR) was conducted among pregnant women in South Africa over a 5-year period after the initiation of a large national antiretroviral treatment program. Analysis of TDR data from 9 surveys conducted between 2005 and 2009 in 2 provinces of South Africa suggests that while TDR remains low (<5%) in Gauteng Province, it may be increasing in KwaZulu-Natal, with the most recent survey showing moderate (5%-15%) levels of resistance to the nonnucleoside reverse transcriptase inhibitor drug class.
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ISSN:1537-6591
1537-6591
DOI:10.1093/cid/cir1017