Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis

Across a variety of adverse life circumstances, such as social isolation and low socioeconomic status, mammalian immune cells have been found to show a conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes. The present study examines whether s...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 41; p. 16574
Main Authors:	Powell, Nicole D, Sloan, Erica K, Bailey, Michael T, Arevalo, Jesusa M G, Miller, Gregory E, Chen, Edith, Kobor, Michael S, Reader, Brenda F, Sheridan, John F, Cole, Steven W
Format:	Journal Article
Language:	English
Published:	United States 08.10.2013
Subjects:	Animals Computational Biology Flow Cytometry Gene Expression Profiling Gene Expression Regulation - physiology Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Humans Male Mice Mice, Inbred C57BL Monocytes - metabolism Myelopoiesis - physiology Propranolol Receptors, Adrenergic, beta - metabolism Social Environment Socioeconomic Factors Stress, Psychological - metabolism Sympathetic Nervous System - physiology Transcription Factors - metabolism Transcriptome - genetics social genomics immunology
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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