LncRNA ARGI Contributes to Virus‐Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN‐Stimulated Genes

Type 1 diabetes (T1D) is a complex autoimmune disease that develops in genetically susceptible individuals. Most T1D‐associated single nucleotide polymorphisms (SNPs) are located in non‐coding regions of the human genome. Interestingly, SNPs in long non‐coding RNAs (lncRNAs) may result in the disrup...

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Bibliographic Details
Published in:	Advanced science Vol. 10; no. 25; pp. e2300063 - n/a
Main Authors:	González‐Moro, Itziar, Garcia‐Etxebarria, Koldo, Mendoza, Luis Manuel, Fernández‐Jiménez, Nora, Mentxaka, Jon, Olazagoitia‐Garmendia, Ane, Arroyo, María Nicol, Sawatani, Toshiaki, Moreno‐Castro, Cristina, Vinci, Chiara, Op de Beek, Anne, Cnop, Miriam, Igoillo‐Esteve, Mariana, Santin, Izortze
Format:	Journal Article
Language:	English
Published:	Germany John Wiley & Sons, Inc 01.09.2023 John Wiley and Sons Inc Wiley
Subjects:	Cells Diabetes Mellitus, Type 1 Disease Gene expression Genomes Humans Infections Inflammation Inflammation - metabolism Insulin Insulin-Secreting Cells long non‐coding RNAs pancreatic β cells Pathogenesis RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal transduction single nucleotide polymorphism Student's t-test Transcriptional Activation - genetics type 1 diabetes Viral infections type 1 diabetes viral infections long non-coding RNAs single nucleotide polymorphism pancreatic β cells
ISSN:	2198-3844, 2198-3844
Online Access:	Get full text
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