Fungal exposome, human health, and unmet needs: A 2022 update with special focus on allergy

Humans inhale, ingest, and touch thousands of fungi each day. The ubiquity and diversity of the fungal kingdom, reflected by its complex taxonomy, are in sharp contrast with our scarce knowledge about its distribution, pathogenic effects, and effective interventions at the environmental and individu...

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Bibliographic Details
Published in:Allergy (Copenhagen) Vol. 77; no. 11; pp. 3199 - 3216
Main Authors: Vitte, Joana, Michel, Moïse, Malinovschi, Andrei, Caminati, Marco, Odebode, Adeyinka, Annesi‐Maesano, Isabella, Caimmi, Davide Paolo, Cassagne, Carole, Demoly, Pascal, Heffler, Enrico, Menu, Estelle, Nwaru, Bright I., Sereme, Youssouf, Ranque, Stéphane, Raulf, Monika, Feleszko, Wojciech, Janson, Christer, Galán, Carmen
Format: Journal Article
Language:English
Published: Denmark Blackwell Publishing Ltd 01.11.2022
Wiley
Subjects:
allergic broncho-pulmonary aspergillosis
allergic bronchopulmonary aspergillosis
Allergies
Allergology
allergy
Aspergillosis
Biomarkers
Clinical Medicine
Epidemiology
Exposome
Fungal infections
Fungi
fungus
Fysiologi
Health Sciences
human health
Humans
Hypersensitivity
Hälsovetenskap
immunoglobulin
Immunology
Klinisk medicin
Life Sciences
Lung Medicine
Lungmedicin
microbiota
mycobiota
Physiology
taxonomy
yeast
allergy
hypersensitivity
allergic bronchopulmonary aspergillosis
fungus
exposome
ISSN:0105-4538, 1398-9995, 1398-9995
Online Access:Get full text
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Summary:Humans inhale, ingest, and touch thousands of fungi each day. The ubiquity and diversity of the fungal kingdom, reflected by its complex taxonomy, are in sharp contrast with our scarce knowledge about its distribution, pathogenic effects, and effective interventions at the environmental and individual levels. Here, we present an overview of salient features of fungi as permanent players of the human exposome and key determinants of human health, through the lens of fungal allergy and other fungal hypersensitivity reactions. Improved understanding of the fungal exposome sheds new light on the epidemiology of fungal‐related hypersensitivity diseases, their immunological substratum, the currently available methods, and biomarkers for environmental and medical fungi. Unmet needs are described and potential approaches are highlighted as perspectives.
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ISSN:0105-4538
1398-9995
1398-9995
DOI:10.1111/all.15483