Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)

Cutaneous T-cell lymphoma (CTCL) is an incurable non-Hodgkin lymphoma of the skin-homing T cell. In early-stage disease, lesions are limited to the skin, but in later-stage disease, the tumor cells can escape into the blood, the lymph nodes, and at times the visceral organs. To clarify the genomic b...

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Vydané v:	Blood Ročník 130; číslo 12; s. 1430
Hlavní autori:	Park, Joonhee, Yang, Jingyi, Wenzel, Alexander T, Ramachandran, Akshaya, Lee, Wung J, Daniels, Jay C, Kim, Juhyun, Martinez-Escala, Estela, Amankulor, Nduka, Pro, Barbara, Guitart, Joan, Mendillo, Marc L, Savas, Jeffrey N, Boggon, Titus J, Choi, Jaehyuk
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 21.09.2017
Predmet:	Amino Acid Sequence Amino Acid Substitution - genetics Base Sequence Genome, Human Genomics HEK293 Cells Humans Jurkat Cells Lymphoma, T-Cell, Cutaneous - genetics Microfilament Proteins - chemistry Microfilament Proteins - genetics Mutation - genetics NF-kappa B - metabolism Oncogenes Receptors, Antigen, T-Cell - metabolism rhoA GTP-Binding Protein - genetics Sequence Analysis, DNA Signal Transduction - genetics
ISSN:	1528-0020, 1528-0020
On-line prístup:	Zistit podrobnosti o prístupe
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