On the role of mechanics in driving mesenchymal-to-epithelial transitions

[Display omitted] •Mechanical cues initiate, propagate, and stabilize polarization in MET.•Spectrum of METs range from all-at-once epithelialization to single cell METs.•Early development, organogenesis, cancer progression share basic MET framework.•Comparative analysis of MET and their relation to...

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Veröffentlicht in:	Seminars in cell & developmental biology Jg. 67; S. 113 - 122
Hauptverfasser:	Kim, Hye Young, Jackson, Timothy R., Davidson, Lance A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.07.2017
Schlagworte:	Animals Biomechanical Phenomena Cadherins - genetics Cadherins - metabolism Cell and tissue polarity Cell Division Cell mechanics Cell Polarity Cellular Reprogramming - genetics Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Embryo, Mammalian Embryo, Nonmammalian EMT Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - genetics Epithelial-to-mesenchymal transition Epithelialization Extracellular Matrix - chemistry Extracellular Matrix - metabolism Humans Mechanotransduction, Cellular Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism MET Morphogenesis - genetics Phenotypic plasticity Polarization Re-epithelialization Reverse-EMT Vimentin - genetics Vimentin - metabolism Cell and tissue polarity Polarization Epithelialization Re-epithelialization Reverse-EMT Epithelial-to-mesenchymal transition Phenotypic plasticity MET EMT Cell mechanics
ISSN:	1084-9521, 1096-3634
Online-Zugang:	Volltext
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