On the role of mechanics in driving mesenchymal-to-epithelial transitions

[Display omitted] •Mechanical cues initiate, propagate, and stabilize polarization in MET.•Spectrum of METs range from all-at-once epithelialization to single cell METs.•Early development, organogenesis, cancer progression share basic MET framework.•Comparative analysis of MET and their relation to...

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Published in:Seminars in cell & developmental biology Vol. 67; pp. 113 - 122
Main Authors: Kim, Hye Young, Jackson, Timothy R., Davidson, Lance A.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.07.2017
Subjects:
Animals
Biomechanical Phenomena
Cadherins - genetics
Cadherins - metabolism
Cell and tissue polarity
Cell Division
Cell mechanics
Cell Polarity
Cellular Reprogramming - genetics
Drosophila melanogaster - genetics
Drosophila melanogaster - growth & development
Drosophila melanogaster - metabolism
Embryo, Mammalian
Embryo, Nonmammalian
EMT
Epithelial Cells - cytology
Epithelial Cells - metabolism
Epithelial-Mesenchymal Transition - genetics
Epithelial-to-mesenchymal transition
Epithelialization
Extracellular Matrix - chemistry
Extracellular Matrix - metabolism
Humans
Mechanotransduction, Cellular
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
MET
Morphogenesis - genetics
Phenotypic plasticity
Polarization
Re-epithelialization
Reverse-EMT
Vimentin - genetics
Vimentin - metabolism
Cell and tissue polarity
Polarization
Epithelialization
Re-epithelialization
Reverse-EMT
Epithelial-to-mesenchymal transition
Phenotypic plasticity
MET
EMT
Cell mechanics
ISSN:1084-9521, 1096-3634
Online Access:Get full text
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Summary:[Display omitted] •Mechanical cues initiate, propagate, and stabilize polarization in MET.•Spectrum of METs range from all-at-once epithelialization to single cell METs.•Early development, organogenesis, cancer progression share basic MET framework.•Comparative analysis of MET and their relation to EMTs needs to be explored further. The mesenchymal-to-epithelial transition (MET) is an intrinsically mechanical process describing a multi-step progression where autonomous mesenchymal cells gradually become tightly linked, polarized epithelial cells. METs are fundamental to a wide range of biological processes, including the evolution of multicellular organisms, generation of primary and secondary epithelia during development and organogenesis, and the progression of diseases including cancer. In these cases, there is an interplay between the establishment of cell polarity and the mechanics of neighboring cells and microenvironment. In this review, we highlight a spectrum of METs found in normal development as well as in pathological lesions, and provide insight into the critical role mechanics play at each step. We define MET as an independent process, distinct from a reverse-EMT, and propose questions to further explore the cellular and physical mechanisms of MET.
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contributed equally
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2016.05.011