On the role of mechanics in driving mesenchymal-to-epithelial transitions

[Display omitted] •Mechanical cues initiate, propagate, and stabilize polarization in MET.•Spectrum of METs range from all-at-once epithelialization to single cell METs.•Early development, organogenesis, cancer progression share basic MET framework.•Comparative analysis of MET and their relation to...

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Vydané v:	Seminars in cell & developmental biology Ročník 67; s. 113 - 122
Hlavní autori:	Kim, Hye Young, Jackson, Timothy R., Davidson, Lance A.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Elsevier Ltd 01.07.2017
Predmet:	Animals Biomechanical Phenomena Cadherins - genetics Cadherins - metabolism Cell and tissue polarity Cell Division Cell mechanics Cell Polarity Cellular Reprogramming - genetics Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Embryo, Mammalian Embryo, Nonmammalian EMT Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - genetics Epithelial-to-mesenchymal transition Epithelialization Extracellular Matrix - chemistry Extracellular Matrix - metabolism Humans Mechanotransduction, Cellular Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism MET Morphogenesis - genetics Phenotypic plasticity Polarization Re-epithelialization Reverse-EMT Vimentin - genetics Vimentin - metabolism Cell and tissue polarity Polarization Epithelialization Re-epithelialization Reverse-EMT Epithelial-to-mesenchymal transition Phenotypic plasticity MET EMT Cell mechanics
ISSN:	1084-9521, 1096-3634
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Popis
Shrnutí:	[Display omitted] •Mechanical cues initiate, propagate, and stabilize polarization in MET.•Spectrum of METs range from all-at-once epithelialization to single cell METs.•Early development, organogenesis, cancer progression share basic MET framework.•Comparative analysis of MET and their relation to EMTs needs to be explored further. The mesenchymal-to-epithelial transition (MET) is an intrinsically mechanical process describing a multi-step progression where autonomous mesenchymal cells gradually become tightly linked, polarized epithelial cells. METs are fundamental to a wide range of biological processes, including the evolution of multicellular organisms, generation of primary and secondary epithelia during development and organogenesis, and the progression of diseases including cancer. In these cases, there is an interplay between the establishment of cell polarity and the mechanics of neighboring cells and microenvironment. In this review, we highlight a spectrum of METs found in normal development as well as in pathological lesions, and provide insight into the critical role mechanics play at each step. We define MET as an independent process, distinct from a reverse-EMT, and propose questions to further explore the cellular and physical mechanisms of MET.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 contributed equally
ISSN:	1084-9521 1096-3634
DOI:	10.1016/j.semcdb.2016.05.011