Itaconate confers tolerance to late NLRP3 inflammasome activation

Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated macrophages. We show that endogenous itaconate is a ke...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 34; no. 10; p. 108756
Main Authors:	Bambouskova, Monika, Potuckova, Lucie, Paulenda, Tomas, Kerndl, Martina, Mogilenko, Denis A., Lizotte, Kate, Swain, Amanda, Hayes, Sebastian, Sheldon, Ryan D., Kim, Hyeryun, Kapadnis, Unnati, Ellis, Abigail E., Isaguirre, Christine, Burdess, Samantha, Laha, Anwesha, Amarasinghe, Gaya K., Chubukov, Victor, Roddy, Thomas P., Diamond, Michael S., Jones, Russell G., Simons, Donald M., Artyomov, Maxim N.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 09.03.2021 Elsevier
Subjects:	Adenosine Triphosphate - pharmacology Animals Caspase 1 - metabolism Hydro-Lyases - deficiency Hydro-Lyases - genetics Hydro-Lyases - metabolism immunometabolism inflammasome Inflammasomes - drug effects Inflammasomes - metabolism innate immunity Interleukin-1beta - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism itaconate Lipopolysaccharides - pharmacology macrophages Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase Type II - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Phosphate-Binding Proteins - genetics Phosphate-Binding Proteins - metabolism Poly I-C - pharmacology Pyroptosis - drug effects Sepsis - chemically induced Sepsis - metabolism Sepsis - pathology Signal Transduction - drug effects Succinates - pharmacology Toll-Like Receptors - chemistry Toll-Like Receptors - metabolism macrophages itaconate innate immunity immunometabolism inflammasome
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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