Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

Somatic hypermutation and class switch recombination are DNA modification reactions that alter the genes encoding antibodies in B lymphocytes. Both of these distinct reactions require activation-induced deaminase (AID) and transcription. Here we show that in Escherichia coli , as in eukaryotic cells...

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Veröffentlicht in:	Nature immunology Jg. 4; H. 5; S. 452 - 456
Hauptverfasser:	Ramiro, Almudena R., Stavropoulos, Pete, Jankovic, Mila, Nussenzweig, Michel C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.05.2003 Nature Publishing Group
Schlagworte:	Animals Base Sequence Biomedical and Life Sciences Biomedicine Cytidine - metabolism Cytidine Deaminase - metabolism Deoxyribonucleic acid DNA DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Bacterial - metabolism DNA, Single-Stranded - chemistry DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism E coli Escherichia coli - genetics Escherichia coli - metabolism Genes, Bacterial Humans Immunoglobulin Class Switching Immunology Infectious Diseases Lymphocytes Models, Immunological Molecular Sequence Data Mutation Plasmids - genetics Recombination, Genetic RNA - genetics RNA - metabolism Somatic Hypermutation, Immunoglobulin Substrate Specificity Transcription, Genetic
ISSN:	1529-2908, 1529-2916
Online-Zugang:	Volltext
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