AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice

Existing therapies for inflammatory bowel disease that are based on broad suppression of inflammation result in variable clinical benefit and unwanted side effects. A potential therapeutic approach for promoting immune tolerance is the in vivo induction of regulatory T cells (Tregs). Here we report...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 17; no. 5; pp. 1318 - 1329
Main Authors:	Goettel, Jeremy A., Gandhi, Roopali, Kenison, Jessica E., Yeste, Ada, Murugaiyan, Gopal, Sambanthamoorthy, Sharmila, Griffith, Alexandra E., Patel, Bonny, Shouval, Dror S., Weiner, Howard L., Snapper, Scott B., Quintana, Francisco J.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 25.10.2016 Elsevier
Subjects:	AHR Animals Colitis - immunology Colitis - metabolism Disease Models, Animal Forkhead Transcription Factors - metabolism humanized mice Humans IBD ITE Mice Receptors, Aryl Hydrocarbon - metabolism T-Lymphocytes, Regulatory - immunology Thiazoles Transforming Growth Factor beta1 - pharmacology treg Trinitrobenzenesulfonic Acid IBD AHR ITE treg humanized mice
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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