Fast-digestive protein supplement for ten days overcomes muscle anabolic resistance in healthy elderly men

Adequate protein intake is crucial to maintain muscle protein content in elderly subjects, but quality of dietary proteins should be considered. The aim was to determine whether soluble milk protein offers an original strategy to increase muscle anabolism in elderly subjects via a synergistic effect...

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Vydané v:	Clinical nutrition (Edinburgh, Scotland) Ročník 35; číslo 3; s. 660 - 668
Hlavní autori:	Walrand, Stéphane, Gryson, Céline, Salles, Jérôme, Giraudet, Christophe, Migné, Carole, Bonhomme, Cécile, Le Ruyet, Pascale, Boirie, Yves
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Elsevier Ltd 01.06.2016 Elsevier / European Society for Clinical Nutrition and Metabolism
Predmet:	actin Aged Beverages Carbon Isotopes casein Caseins - chemistry Caseins - metabolism Caseins - therapeutic use Diet, High-Protein Dietary Supplements Digestion Double-Blind Method Elder Nutritional Physiological Phenomena Elderly Food and Nutrition France Gastroenterology and Hepatology Gene Expression Regulation, Developmental Humans Leucine Leucine - administration & dosage Leucine - metabolism Life Sciences Male men Milk Proteins - chemistry Milk Proteins - metabolism Milk Proteins - therapeutic use mitochondria muscle protein Muscle protein synthesis Muscle Proteins - metabolism Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism muscles myosin pasteurization postprandial state protein content Protein Hydrolysates - chemistry Protein Hydrolysates - metabolism Protein Hydrolysates - therapeutic use protein intake protein sources protein supplements protein synthesis Sarcopenia Sarcopenia - metabolism Sarcopenia - prevention & control Solubility Soluble milk proteins synergism Sarcopenia Leucine Elderly Muscle protein synthesis Soluble milk proteins protéine du lait Synthesis senior citizens anabolisme postprandial personne âgée milk protein Muscle protein
ISSN:	0261-5614, 1532-1983, 1532-1983
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Shrnutí:	Adequate protein intake is crucial to maintain muscle protein content in elderly subjects, but quality of dietary proteins should be considered. The aim was to determine whether soluble milk protein offers an original strategy to increase muscle anabolism in elderly subjects via a synergistic effect of fast-digesting proteins together with a unique essential AA content. We investigated the effect of a 10-day adequate-protein (AP) or high-protein (HP) diet together with the protein source as caseins (CAS) or soluble milk proteins (PRO) on specific muscle protein fractional synthesis rates (FSRs) in healthy elderly men (71.8 ± 2.4 yr, n = 31). The isotopic study consisted of two periods of 4 h each: a post-absorptive and a postprandial period. The fed state was defined by consumption of either 15 g or 30 g of PRO or CAS, given fractionally every 20 min for 4 h. Soluble milk proteins are produced using a membrane process directly from pasteurized milk. Specific muscle protein FSRs were measured during both postabsorptive and postprandial period using a continuous infusion of l-[1-13C]leucine. FSR of sarcoplasmic muscle proteins and actin did not increase significantly in the postprandial state compared to postabsorptive state, whereas myosin FSR rate was increased by feeding whatever the protein source in HP groups (0.024 ± 0.005 vs 0.053 ± 0.011% h−1, P < 0.05 and 0.026 ± 0.004 vs 0.050 ± 0.005% h−1, P < 0.004 for PRO HP and CAS HP) but only with the PRO meal in the AP groups (0.031 ± 0.003 vs 0.062 ± 0.009% h−1, P < 0.03 for PRO AP). Mitochondrial muscle protein FSR was also increased by feeding, irrespective of the protein quantity, but only in PRO meal groups (P < 0.02). Fast-digesting soluble milk proteins improved postprandial muscle protein synthesis, especially mitochondrial muscle proteins and myosin fractional synthesis rates, in elderly subjects.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0261-5614 1532-1983 1532-1983
DOI:	10.1016/j.clnu.2015.04.020