Real life study of three years omalizumab in patients with difficult-to-control asthma

Even though there are multiple options for the treatment of asthma, there still exists a fair group of patients with difficult-to-control asthma. We describe for the first time the real-world effects of three-year omalizumab treatment on patients with difficult-to-control asthma, seen in a social se...

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Bibliographic Details
Published in:Allergologia et immunopathologia Vol. 43; no. 2; p. 120
Main Authors: López Tiro, J Jesús, Contreras, E Angélica Contreras, del Pozo, M Elena Ramírez, Gómez Vera, J, Larenas Linnemann, D
Format: Journal Article
Language:English
Published: Spain 01.03.2015
Subjects:
Adolescent
Adult
Aged
Anti-Asthmatic Agents - therapeutic use
Asthma - drug therapy
Beclomethasone - therapeutic use
Disease Progression
Emergency Medical Services
Female
Humans
Immunoglobulin E - immunology
Male
Mexico
Middle Aged
Omalizumab - therapeutic use
Respiratory Function Tests
Time Factors
Young Adult
Mexico
Emergency room
Asthmatic crisis
Anti-IgE
Omalizumab
Biological
Difficult-to-control asthma
Severe asthma
Asthma exacerbation
Hospitalisation
ISSN:1578-1267, 1578-1267
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Summary:Even though there are multiple options for the treatment of asthma, there still exists a fair group of patients with difficult-to-control asthma. We describe for the first time the real-world effects of three-year omalizumab treatment on patients with difficult-to-control asthma, seen in a social security hospital in a Latin American country. Difficult-to-control asthmatic patients from the out-patient clinic of a regional hospital were recruited to receive a three-year omalizumab course. Efficacy parameters were asthma control test (ACT) score; FEV1; daily beclomethasone maintenance dose; and unplanned visits for asthma exacerbations (emergency room (ER), hospitalisations, intensive care). 52 patients were recruited, 47 completed the three-year treatment (42 female, 15-67 years, mean age 43.5). Comparing efficacy parameters of the year before omalizumab with the 3rd year of omalizumab: mean ACT improved from 12.4 to 20.5, mean FEV1 from 66.3% (standard deviation (SD) 19.1%) to 88.4% (SD 16.2%) of predicted, while mean beclomethasone dose reduced from 1750 to 766 mcg/day and there was a significant reduction in patients experiencing ER visits (from 95% to 19%, p<0.0001), hospitalisation (38% to 2%, p<0.0001) and intensive care (4% to 0, NS). Five patients discontinued omalizumab, two because of an adverse event (anaphylaxis, severe headache, both resolved without sequelae). Omalizumab improved most clinical parameters of Mexican patients with difficult-to-control asthma. Especially the rates of ER visits and hospitalisation were significantly reduced, thus reducing costs. Omalizumab was generally well tolerated.
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ISSN:1578-1267
1578-1267
DOI:10.1016/j.aller.2013.11.008