Prognostic significance of minimal residual disease in high risk B-ALL: a report from Children's Oncology Group study AALL0232

Minimal residual disease (MRD) is highly prognostic in pediatric B-precursor acute lymphoblastic leukemia (B-ALL). In Children's Oncology Group high-risk B-ALL study AALL0232, we investigated MRD in subjects randomized in a 2 × 2 factorial design to receive either high-dose methotrexate (HD-MTX...

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Veröffentlicht in:	Blood Jg. 126; H. 8; S. 964 - 971
Hauptverfasser:	Borowitz, Michael J, Wood, Brent L, Devidas, Meenakshi, Loh, Mignon L, Raetz, Elizabeth A, Salzer, Wanda L, Nachman, James B, Carroll, Andrew J, Heerema, Nyla A, Gastier-Foster, Julie M, Willman, Cheryl L, Dai, Yunfeng, Winick, Naomi J, Hunger, Stephen P, Carroll, William L, Larsen, Eric
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.08.2015
Schlagworte:	Antineoplastic Agents - administration & dosage Asparaginase - administration & dosage Child Child, Preschool Dexamethasone - administration & dosage Disease-Free Survival Dose-Response Relationship, Drug Female Flow Cytometry Humans Induction Chemotherapy Kaplan-Meier Estimate Leucovorin - administration & dosage Maintenance Chemotherapy Male Methotrexate - administration & dosage Neoplasm, Residual - pathology Polyethylene Glycols - administration & dosage Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Prednisone - administration & dosage Prognosis Proportional Hazards Models Risk Factors
ISSN:	1528-0020
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