SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity

Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6). SIRT6-sensitive cancer cells bear mutations that activate phosphatidylinositol-3-kinase (PI3K) signa...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 18; H. 8; S. 1858 - 1868
Hauptverfasser:	Ioris, Rafael M., Galié, Mirco, Ramadori, Giorgio, Anderson, Jason G., Charollais, Anne, Konstantinidou, Georgia, Brenachot, Xavier, Aras, Ebru, Goga, Algera, Ceglia, Nicholas, Sebastián, Carlos, Martinvalet, Denis, Mostoslavsky, Raul, Baldi, Pierre, Coppari, Roberto
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 21.02.2017 Cell Press Elsevier
Schlagworte:	Acetylation Animals cancer stemness Carcinogenesis - metabolism Cell Line, Tumor Cell Proliferation - physiology Humans Mice Mice, Inbred NOD Mice, SCID Mutation - physiology Neoplasms - metabolism Neoplastic Stem Cells - metabolism Phosphatidylinositol 3-Kinases - metabolism PI3K Signal Transduction - physiology SIRT6 Sirtuins - metabolism Transcription, Genetic - physiology PI3K SIRT6 cancer stemness
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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