Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1

Recent studies show that endothelial cell protein C receptor (EPCR) interacts with diverse ligands, in addition to its known ligands protein C and activated protein C (APC). We showed in earlier studies that procoagulant clotting factor VIIa (FVIIa) binds EPCR and downregulates EPCR-mediated anticoa...

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Bibliographic Details
Published in:	Blood Vol. 131; no. 21; p. 2379
Main Authors:	Kondreddy, Vijay, Wang, Jue, Keshava, Shiva, Esmon, Charles T, Rao, L Vijaya Mohan, Pendurthi, Usha R
Format:	Journal Article
Language:	English
Published:	United States 24.05.2018
Subjects:	Animals beta-Arrestins - metabolism Biomarkers Endothelial Protein C Receptor - genetics Endothelial Protein C Receptor - metabolism Factor VIIa - metabolism Gene Expression Regulation Human Umbilical Vein Endothelial Cells - metabolism Humans Inflammation - genetics Inflammation - metabolism Inflammation Mediators - metabolism Lipopolysaccharides - adverse effects Lipopolysaccharides - immunology Mice Receptor, PAR-1 - genetics Receptor, PAR-1 - metabolism Signal Transduction Tumor Necrosis Factor-alpha - metabolism
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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