Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive Classes

It has been posited that anti-tumoral innate activation is driven by derepression of endogenous repeats. We compared RNA sequencing protocols to assess repeat transcriptomes in The Cancer Genome Atlas (TCGA). Although poly(A) selection efficiently detects coding genes, most non-coding genes, and lim...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 23; no. 2; pp. 512 - 521
Main Authors:	Solovyov, Alexander, Vabret, Nicolas, Arora, Kshitij S., Snyder, Alexandra, Funt, Samuel A., Bajorin, Dean F., Rosenberg, Jonathan E., Bhardwaj, Nina, Ting, David T., Greenbaum, Benjamin D.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 10.04.2018 Elsevier
Subjects:	Antibodies, Monoclonal - therapeutic use cancer immunity Cluster Analysis Endogenous Retroviruses - metabolism ERV HSATII Humans Immunotherapy innate immunity Kaplan-Meier Estimate Long Interspersed Nucleotide Elements - genetics microenvironment Neoplasms - genetics Neoplasms - mortality Neoplasms - therapy repetitive elements Repetitive Sequences, Nucleic Acid - genetics RNA-seq Sequence Analysis, RNA T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - metabolism Transcriptome microenvironment HSATII RNA-seq innate immunity immunotherapy ERV repetitive elements cancer immunity
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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