Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies

Summary Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome‐wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)‐infected cells. At the time of MHV‐indu...

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Bibliographic Details
Published in:	Cellular microbiology Vol. 9; no. 9; pp. 2218 - 2229
Main Authors:	Raaben, Matthijs, Groot Koerkamp, Marian J. A., Rottier, Peter J. M., De Haan, Cornelis A. M.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.09.2007 John Wiley & Sons, Inc
Subjects:	Animals Cells, Cultured Coronavirus Coronavirus Infections - metabolism COVID-19 Cytoplasmic Granules - metabolism Decay Eukaryotic Initiation Factor-2 - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - virology Hepatitis Hepatitis, Viral, Animal - metabolism Humans Mice Molecular Sequence Data Murine hepatitis virus - genetics Murine hepatitis virus - physiology Oligonucleotide Array Sequence Analysis Original Protein Biosynthesis Protein synthesis RNA Stability RNA, Messenger - metabolism Transcription, Genetic Virus Replication
ISSN:	1462-5814, 1462-5822
Online Access:	Get full text
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