Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies

Summary Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome‐wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)‐infected cells. At the time of MHV‐indu...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Cellular microbiology Ročník 9; číslo 9; s. 2218 - 2229
Hlavní autoři:	Raaben, Matthijs, Groot Koerkamp, Marian J. A., Rottier, Peter J. M., De Haan, Cornelis A. M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Oxford, UK Blackwell Publishing Ltd 01.09.2007 John Wiley & Sons, Inc
Témata:	Animals Cells, Cultured Coronavirus Coronavirus Infections - metabolism COVID-19 Cytoplasmic Granules - metabolism Decay Eukaryotic Initiation Factor-2 - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - virology Hepatitis Hepatitis, Viral, Animal - metabolism Humans Mice Molecular Sequence Data Murine hepatitis virus - genetics Murine hepatitis virus - physiology Oligonucleotide Array Sequence Analysis Original Protein Biosynthesis Protein synthesis RNA Stability RNA, Messenger - metabolism Transcription, Genetic Virus Replication
ISSN:	1462-5814, 1462-5822
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Summary Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome‐wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)‐infected cells. At the time of MHV‐induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation‐related factors, was observed. This downregulation, which is reminiscent of a cellular stress response, was dependent on viral replication and caused by mRNA decay. Concomitantly, phosphorylation of the eukaryotic translation initiation factor 2α was increased in MHV‐infected cells. In addition, stress granules and processing bodies appeared, which are sites for mRNA stalling and degradation respectively. We propose that MHV replication induces host translational shutoff by triggering an integrated stress response. However, MHV replication per se does not appear to benefit from the inhibition of host protein synthesis, at least in vitro, since viral replication was not negatively affected but rather enhanced in cells with impaired translational shutoff.
AbstractList	Summary Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome‐wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)‐infected cells. At the time of MHV‐induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation‐related factors, was observed. This downregulation, which is reminiscent of a cellular stress response, was dependent on viral replication and caused by mRNA decay. Concomitantly, phosphorylation of the eukaryotic translation initiation factor 2α was increased in MHV‐infected cells. In addition, stress granules and processing bodies appeared, which are sites for mRNA stalling and degradation respectively. We propose that MHV replication induces host translational shutoff by triggering an integrated stress response. However, MHV replication per se does not appear to benefit from the inhibition of host protein synthesis, at least in vitro, since viral replication was not negatively affected but rather enhanced in cells with impaired translational shutoff. Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome-wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)-infected cells. At the time of MHV-induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation-related factors, was observed. This downregulation, which is reminiscent of a cellular stress response, was dependent on viral replication and caused by mRNA decay. Concomitantly, phosphorylation of the eukaryotic translation initiation factor 2α was increased in MHV-infected cells. In addition, stress granules and processing bodies appeared, which are sites for mRNA stalling and degradation respectively. We propose that MHV replication induces host translational shutoff by triggering an integrated stress response. However, MHV replication per se does not appear to benefit from the inhibition of host protein synthesis, at least in vitro , since viral replication was not negatively affected but rather enhanced in cells with impaired translational shutoff. Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome-wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)-infected cells. At the time of MHV-induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation-related factors, was observed. This downregulation, which is reminiscent of a cellular stress response, was dependent on viral replication and caused by mRNA decay. Concomitantly, phosphorylation of the eukaryotic translation initiation factor 2alpha was increased in MHV-infected cells. In addition, stress granules and processing bodies appeared, which are sites for mRNA stalling and degradation respectively. We propose that MHV replication induces host translational shutoff by triggering an integrated stress response. However, MHV replication per se does not appear to benefit from the inhibition of host protein synthesis, at least in vitro, since viral replication was not negatively affected but rather enhanced in cells with impaired translational shutoff. Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome-wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)-infected cells. At the time of MHV-induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation-related factors, was observed. This downregulation, which is reminiscent of a cellular stress response, was dependent on viral replication and caused by mRNA decay. Concomitantly, phosphorylation of the eukaryotic translation initiation factor 2alpha was increased in MHV-infected cells. In addition, stress granules and processing bodies appeared, which are sites for mRNA stalling and degradation respectively. We propose that MHV replication induces host translational shutoff by triggering an integrated stress response. However, MHV replication per se does not appear to benefit from the inhibition of host protein synthesis, at least in vitro, since viral replication was not negatively affected but rather enhanced in cells with impaired translational shutoff.Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome-wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)-infected cells. At the time of MHV-induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation-related factors, was observed. This downregulation, which is reminiscent of a cellular stress response, was dependent on viral replication and caused by mRNA decay. Concomitantly, phosphorylation of the eukaryotic translation initiation factor 2alpha was increased in MHV-infected cells. In addition, stress granules and processing bodies appeared, which are sites for mRNA stalling and degradation respectively. We propose that MHV replication induces host translational shutoff by triggering an integrated stress response. However, MHV replication per se does not appear to benefit from the inhibition of host protein synthesis, at least in vitro, since viral replication was not negatively affected but rather enhanced in cells with impaired translational shutoff. Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome-wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)-infected cells. At the time of MHV-induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation-related factors, was observed. This downregulation, which is reminiscent of a cellular stress response, was dependent on viral replication and caused by mRNA decay. Concomitantly, phosphorylation of the eukaryotic translation initiation factor 2 alpha was increased in MHV-infected cells. In addition, stress granules and processing bodies appeared, which are sites for mRNA stalling and degradation respectively. We propose that MHV replication induces host translational shutoff by triggering an integrated stress response. However, MHV replication per se does not appear to benefit from the inhibition of host protein synthesis, at least in vitro, since viral replication was not negatively affected but rather enhanced in cells with impaired translational shutoff.
Author	Raaben, Matthijs Groot Koerkamp, Marian J. A. De Haan, Cornelis A. M. Rottier, Peter J. M.
AuthorAffiliation	1 Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands 2 Microarray Facility, UMC Utrecht, Department of Physiological Chemistry, Utrecht, the Netherlands
AuthorAffiliation_xml	– name: 2 Microarray Facility, UMC Utrecht, Department of Physiological Chemistry, Utrecht, the Netherlands – name: 1 Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Author_xml	– sequence: 1 givenname: Matthijs surname: Raaben fullname: Raaben, Matthijs – sequence: 2 givenname: Marian J. A. surname: Groot Koerkamp fullname: Groot Koerkamp, Marian J. A. – sequence: 3 givenname: Peter J. M. surname: Rottier fullname: Rottier, Peter J. M. – sequence: 4 givenname: Cornelis A. M. surname: De Haan fullname: De Haan, Cornelis A. M.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/17490409$$D View this record in MEDLINE/PubMed
BookMark	eNqNks9u1DAQxiNURP_AKyCLA6du8HidOJYQUrWCtlILEoKz5djOxqvEDnbSdl-GZ8XplgV6Kb54pPnmZ8_Md5wdOO9MliHAOaTzbpMDLcmiqAjJCcYsx5gXkN89y472iYN9DPQwO45xgzGUDOBFdgiMckwxP8p-XvspGtSaQY52tBEpH7yTNzZMEQUzdFalhHfIOj0pE1Hr44jGIF3s7hOyQ7GdRt80SDqN-q-fz5A2Sm5P0a0d28Rzyvd2lG5EjQ_9juYbFMdgYkTrhJq6BJ6rh-DTG9G6Naq9tia-zJ43sovm1cN9kn3_9PHb6mJx9eX8cnV2tVAF4bBQuCpIrTGo2tCiqSoAQ4nivGGlogaYAq41VowBLWrGWCFLzCmpK00p17A8yT7suMNU90Yr41KLnRiC7WXYCi-t-DfjbCvW_kYwKAkwlgBvHwDB_5hMHEVvozJdJ51JExZlBWVZ4aeFBNOSYVwl4ZtHwo2fQpr3rFkWFV3yWfT673_vP_x7wX8aU8HHGEwjVNrFvIPUhu0EYDE7SmzEbBYxG0fMjhL3jhJ3CVA9AuzfeLr0_a701nZm-991YnV9mYLlLxC15qI
CitedBy_id	crossref_primary_10_3390_v3112328 crossref_primary_10_1080_07391102_2022_2146752 crossref_primary_10_3390_v12050536 crossref_primary_10_1128_JVI_00625_10 crossref_primary_10_3389_fcimb_2017_00111 crossref_primary_10_7554_eLife_42037 crossref_primary_10_1111_j_1742_4658_2008_06564_x crossref_primary_10_1146_annurev_micro_110520_023212 crossref_primary_10_3390_v8070184 crossref_primary_10_3390_v8070180 crossref_primary_10_1002_wrna_1162 crossref_primary_10_1371_journal_pone_0051495 crossref_primary_10_1016_j_vetmic_2022_109494 crossref_primary_10_1128_JVI_02420_15 crossref_primary_10_1128_JVI_00485_10 crossref_primary_10_1016_j_fsi_2015_07_018 crossref_primary_10_1002_wrna_1614 crossref_primary_10_1080_07391102_2020_1839563 crossref_primary_10_2217_fvl_11_108 crossref_primary_10_1128_JVI_02305_12 crossref_primary_10_1016_j_virusres_2013_06_012 crossref_primary_10_1128_JVI_01779_07 crossref_primary_10_1371_journal_ppat_1010724 crossref_primary_10_1016_j_bbrc_2016_05_094 crossref_primary_10_1016_j_vetmic_2019_108392 crossref_primary_10_1128_jvi_00686_22 crossref_primary_10_1128_MCB_06665_11 crossref_primary_10_1002_1873_3468_14229 crossref_primary_10_1016_j_virol_2010_07_006 crossref_primary_10_1128_JVI_03213_12 crossref_primary_10_1371_journal_pone_0182059 crossref_primary_10_1128_JVI_00627_16 crossref_primary_10_1186_1477_5956_10_24 crossref_primary_10_1128_JVI_00902_18 crossref_primary_10_1128_JVI_00017_08 crossref_primary_10_1128_JVI_06265_11 crossref_primary_10_1128_JVI_02220_10 crossref_primary_10_1146_annurev_virology_100114_055218 crossref_primary_10_1371_journal_ppat_1001329 crossref_primary_10_1038_s41586_020_2286_9 crossref_primary_10_1111_cmi_12565 crossref_primary_10_1016_j_virusres_2012_06_004 crossref_primary_10_3389_fmicb_2022_931922 crossref_primary_10_1091_mbc_e08_05_0499 crossref_primary_10_1128_JVI_00260_10 crossref_primary_10_3109_21678421_2014_881377 crossref_primary_10_1016_j_chom_2010_05_013 crossref_primary_10_1371_journal_ppat_1002090 crossref_primary_10_1080_03079457_2022_2109453 crossref_primary_10_4167_jbv_2012_42_3_247 crossref_primary_10_1186_1471_2164_9_221 crossref_primary_10_1128_JVI_05888_11 crossref_primary_10_1096_fj_202001351 crossref_primary_10_1007_s12035_017_0861_3 crossref_primary_10_1007_s12250_018_0040_3 crossref_primary_10_1002_mds_28084 crossref_primary_10_3389_fmicb_2021_814635 crossref_primary_10_1093_nar_gkae921 crossref_primary_10_1016_j_ejphar_2021_173977 crossref_primary_10_1016_j_it_2014_07_006 crossref_primary_10_1093_nar_gkaa1116 crossref_primary_10_1128_JVI_01245_08 crossref_primary_10_1186_1471_2164_10_350 crossref_primary_10_1371_journal_pone_0178408 crossref_primary_10_1128_JVI_07101_11 crossref_primary_10_1016_j_vetmic_2025_110559 crossref_primary_10_1016_j_phrs_2020_105143 crossref_primary_10_1128_JVI_02831_13 crossref_primary_10_3389_fmicb_2023_1138864 crossref_primary_10_1016_j_virol_2012_11_017 crossref_primary_10_1128_JVI_01251_17 crossref_primary_10_1128_JVI_01695_21 crossref_primary_10_1146_annurev_virology_031413_085505 crossref_primary_10_1039_D1SC04839B crossref_primary_10_3390_v11060563 crossref_primary_10_1016_j_brainres_2016_05_022 crossref_primary_10_1038_onc_2011_120 crossref_primary_10_1128_JVI_01320_09 crossref_primary_10_1002_pmic_201000309 crossref_primary_10_1016_j_tim_2012_02_001 crossref_primary_10_3389_fcimb_2019_00336 crossref_primary_10_1371_journal_ppat_1005982 crossref_primary_10_1371_journal_ppat_1008690 crossref_primary_10_1099_vir_0_049064_0 crossref_primary_10_1016_j_antiviral_2022_105451 crossref_primary_10_1016_j_intimp_2022_108764 crossref_primary_10_1128_JVI_00589_18 crossref_primary_10_3389_fmicb_2021_805472 crossref_primary_10_1016_j_vetmic_2024_109988 crossref_primary_10_3390_v6082991 crossref_primary_10_1128_JVI_03197_14 crossref_primary_10_1016_j_cellsig_2010_08_011 crossref_primary_10_1016_j_it_2022_02_001 crossref_primary_10_1128_JVI_00431_18 crossref_primary_10_3389_fncel_2015_00423 crossref_primary_10_3389_fmicb_2015_00804 crossref_primary_10_1128_JVI_07207_11
Cites_doi	10.1128/JVI.76.23.11989-12000.2002 10.1196/annals.1359.026 10.1083/jcb.200309008 10.1038/sj.embor.embor798 10.1099/0022-1317-67-5-923 10.1016/j.semcdb.2004.11.011 10.1073/pnas.0603144103 10.1128/JVI.74.19.8793-8802.2000 10.1038/ng1502 10.1097/00004647-199712000-00004 10.1007/978-1-4757-0456-3_17 10.1128/JVI.02336-05 10.1128/MCB.24.12.5534-5547.2004 10.1128/MMBR.64.4.709-724.2000 10.1091/mbc.e04-08-0715 10.1128/JVI.79.2.884-895.2005 10.1093/nar/30.4.e15 10.1261/rna.5810203 10.1083/jcb.147.7.1431 10.1128/JVI.78.16.8582-8592.2004 10.1128/JVI.00659-06 10.1083/jcb.200512082 10.1074/jbc.M313724200 10.1128/JVI.68.10.6815-6819.1994 10.1091/mbc.e05-02-0124 10.1261/rna.7258505 10.1128/JVI.74.3.1393-1406.2000 10.1091/mbc.12.2.323 10.1016/S0968-0004(03)00029-X 10.1046/j.1432-1327.1999.00780.x 10.1006/viro.1994.1383 10.1016/0042-6822(79)90467-7 10.1016/S0079-6603(08)60034-3 10.1128/JVI.78.11.6048-6054.2004 10.1128/JVI.77.16.8801-8811.2003 10.1128/JVI.74.11.4967-4978.2000 10.1016/S0021-9258(18)47829-5 10.1091/mbc.11.12.4241 10.1242/jcs.115.16.3227 10.1091/mbc.01-11-0544 10.1038/nm1024 10.1128/JVI.39.3.823-834.1981 10.1074/jbc.M212992200 10.1128/JVI.79.20.12742-12751.2005 10.1038/ncb1333 10.1128/JVI.80.4.2019-2033.2006 10.1083/jcb.200502088 10.1016/S0022-2836(03)00865-9 10.1017/S1355838202021726 10.1073/pnas.091062498 10.1096/fasebj.10.12.8903508 10.1038/16729 10.1038/359644a0 10.1128/MCB.21.23.7971-7980.2001 10.1056/NEJMoa030747 10.1007/978-1-4615-2996-5_18 10.1074/jbc.M412882200 10.1128/JVI.40.2.350-357.1981 10.1016/S1097-2765(01)00265-9 10.1099/vir.0.81611-0 10.1016/j.micinf.2004.11.004 10.1099/vir.0.81756-0
ContentType	Journal Article
Copyright	2007 The Authors; Journal compilation © 2007 Blackwell Publishing Ltd
Copyright_xml	– notice: 2007 The Authors; Journal compilation © 2007 Blackwell Publishing Ltd
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QL 7T7 7U9 8FD C1K FR3 H94 M7N P64 7TM 7X8 5PM
DOI	10.1111/j.1462-5822.2007.00951.x
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Bacteriology Abstracts (Microbiology B) Industrial and Applied Microbiology Abstracts (Microbiology A) Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Nucleic Acids Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Technology Research Database Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Nucleic Acids Abstracts MEDLINE - Academic
DatabaseTitleList	Virology and AIDS Abstracts MEDLINE MEDLINE - Academic AIDS and Cancer Research Abstracts
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
DocumentTitleAlternate	M. Raaben, M. J. A. Groot Koerkamp, P. J. M. Rottier and C. A. M. de Haan
EISSN	1462-5822
EndPage	2229
ExternalDocumentID	PMC7162177 1318004441 17490409 10_1111_j_1462_5822_2007_00951_x CMI951
Genre	article Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- .3N .GA .GJ .Y3 05W 0R~ 10A 1OC 24P 29B 2WC 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 A8Z AAESR AAEVG AAHHS AAJEY AAONW AAZKR ABCQN ABCUV ABDBF ABEML ABPVW ACAHQ ACCFJ ACCMX ACFBH ACGFS ACMXC ACPOU ACPRK ACSCC ACUHS ACXQS ADBBV ADEOM ADIYS ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIMD AENEX AEQDE AEUQT AFBPY AFEBI AFGKR AFPWT AFRAH AFZJQ AIACR AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS AMBMR AMYDB ATUGU AZBYB AZVAB BAFTC BAWUL BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EAD EAP EBD EBS EDH EJD EMB EMK EMOBN ESX F00 F01 F04 F5P FIJ FUBAC G-S G.N GODZA GROUPED_DOAJ H.X HF~ HZI HZ~ IHE IPNFZ IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MK4 MM. MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 R.K RHX ROL RX1 SUPJJ SV3 TEORI TR2 TUS UB1 W8V W99 WBKPD WIH WIJ WIK WIN WNSPC WOHZO WQJ WRC WXI WYISQ XG1 ZZTAW ~IA ~KM ~WT AAMMB AAYXX ABUWG AEFGJ AEUYN AFFHD AFKRA AGXDD AIDQK AIDYY ALUQN BANNL BBNVY BENPR BHPHI CCPQU CITATION HCIFZ M7P O8X PHGZM PHGZT PQGLB CGR CUY CVF ECM EIF NPM 7QL 7T7 7U9 8FD C1K FR3 H94 M7N P64 7TM ESTFP 7X8 5PM
ID	FETCH-LOGICAL-c5291-c0852bd01cbe45f8811e42c99f76c4e17c19dd0c77145b7775a60942b8d449d13
IEDL.DBID	WIN
ISICitedReferencesCount	109
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000248666600011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1462-5814
IngestDate	Tue Sep 30 16:59:33 EDT 2025 Mon Sep 08 17:54:07 EDT 2025 Sat Sep 27 19:56:20 EDT 2025 Fri Jul 25 11:02:55 EDT 2025 Thu Apr 03 07:09:42 EDT 2025 Sat Nov 29 02:09:48 EST 2025 Tue Nov 18 22:32:26 EST 2025 Wed Jan 22 16:36:49 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	9
Language	English
License	http://doi.wiley.com/10.1002/tdm_license_1.1 This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c5291-c0852bd01cbe45f8811e42c99f76c4e17c19dd0c77145b7775a60942b8d449d13
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://pubmed.ncbi.nlm.nih.gov/PMC7162177
PMID	17490409
PQID	203584398
PQPubID	46747
PageCount	12
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_7162177 proquest_miscellaneous_68166807 proquest_miscellaneous_20467008 proquest_journals_203584398 pubmed_primary_17490409 crossref_citationtrail_10_1111_j_1462_5822_2007_00951_x crossref_primary_10_1111_j_1462_5822_2007_00951_x wiley_primary_10_1111_j_1462_5822_2007_00951_x_CMI951
PublicationCentury	2000
PublicationDate	September 2007
PublicationDateYYYYMMDD	2007-09-01
PublicationDate_xml	– month: 09 year: 2007 text: September 2007
PublicationDecade	2000
PublicationPlace	Oxford, UK
PublicationPlace_xml	– name: Oxford, UK – name: England – name: Oxford
PublicationTitle	Cellular microbiology
PublicationTitleAlternate	Cell Microbiol
PublicationYear	2007
Publisher	Blackwell Publishing Ltd John Wiley & Sons, Inc
Publisher_xml	– name: Blackwell Publishing Ltd – name: John Wiley & Sons, Inc
References	1987; 262 2004; 165 1981; 142 2002; 13 2004; 24 2002; 115 1994; 68 2006; 172 2003; 278 1981; 40 2000 2000; 11 2004; 78 2003; 9 1992; 359 1997; 17 2003; 4 1981; 39 2005; 37 2001; 12 1998; 58 2005; 79 2001; 98 2002; 30 2002; 76 2002; 8 2000; 64 1999; 147 1999; 265 1996; 10 2003; 331 2005; 1058 2003; 77 2001; 21 1979; 94 1993; 342 2004; 10 2005; 280 2006; 80 2003; 348 2004; 279 1994; 202 2001; 7 2005; 287 2006; 87 1986; 67 2005; 169 2004; 15 2000; 74 2005; 7 2007; 81 2003; 28 1999; 397 2005; 16 2005; 11 2006; 103 Kyuwa (10.1111/j.1462-5822.2007.00951.x-BIB13) 1994; 68 Tebo (10.1111/j.1462-5822.2007.00951.x-BIB43) 2003; 278 Bosch (10.1111/j.1462-5822.2007.00951.x-BIB56) 2003; 77 Eystathioy (10.1111/j.1462-5822.2007.00951.x-BIB34) 2002; 13 Li (10.1111/j.1462-5822.2007.00951.x-BIB53) 2002; 76 Eystathioy (10.1111/j.1462-5822.2007.00951.x-BIB25) 2003; 9 DeGracia (10.1111/j.1462-5822.2007.00951.x-BIB63) 1997; 17 McEwen (10.1111/j.1462-5822.2007.00951.x-BIB33) 2005; 280 Anderson (10.1111/j.1462-5822.2007.00951.x-BIB23) 2006; 172 van de Peppel (10.1111/j.1462-5822.2007.00951.x-BIB59) 2003; 4 Leong (10.1111/j.1462-5822.2007.00951.x-BIB44) 2005; 7 Causton (10.1111/j.1462-5822.2007.00951.x-BIB46) 2001; 12 Tusher (10.1111/j.1462-5822.2007.00951.x-BIB61) 2001; 98 Pasternak (10.1111/j.1462-5822.2007.00951.x-BIB5) 2006; 87 Yang (10.1111/j.1462-5822.2007.00951.x-BIB60) 2002; 30 Roepman (10.1111/j.1462-5822.2007.00951.x-BIB58) 2005; 37 Snijder (10.1111/j.1462-5822.2007.00951.x-BIB7) 2003; 331 Tahara (10.1111/j.1462-5822.2007.00951.x-BIB54) 1993; 342 de Haan (10.1111/j.1462-5822.2007.00951.x-BIB57) 2000; 74 Versteeg (10.1111/j.1462-5822.2007.00951.x-BIB42) 2006; 87 Brostrom (10.1111/j.1462-5822.2007.00951.x-BIB15) 1998; 58 Ma (10.1111/j.1462-5822.2007.00951.x-BIB41) 2004; 279 de Haan (10.1111/j.1462-5822.2007.00951.x-BIB62) 2004; 78 Kaufman (10.1111/j.1462-5822.2007.00951.x-BIB19) 2000 Schneider (10.1111/j.1462-5822.2007.00951.x-BIB39) 2003; 28 Cheadle (10.1111/j.1462-5822.2007.00951.x-BIB32) 2005; 1058 Gasch (10.1111/j.1462-5822.2007.00951.x-BIB45) 2000; 11 Cougot (10.1111/j.1462-5822.2007.00951.x-BIB26) 2004; 165 Liu (10.1111/j.1462-5822.2007.00951.x-BIB27) 2005; 7 Ingelfinger (10.1111/j.1462-5822.2007.00951.x-BIB24) 2002; 8 Tahara (10.1111/j.1462-5822.2007.00951.x-BIB11) 1994; 202 van der Hoek (10.1111/j.1462-5822.2007.00951.x-BIB3) 2004; 10 Kamitani (10.1111/j.1462-5822.2007.00951.x-BIB14) 2006; 103 Law (10.1111/j.1462-5822.2007.00951.x-BIB48) 2007; 81 Clemens (10.1111/j.1462-5822.2007.00951.x-BIB49) 2005; 16 Lu (10.1111/j.1462-5822.2007.00951.x-BIB20) 2001; 21 Robb (10.1111/j.1462-5822.2007.00951.x-BIB30) 1979; 94 Anderson (10.1111/j.1462-5822.2007.00951.x-BIB22) 2002; 115 Kedersha (10.1111/j.1462-5822.2007.00951.x-BIB28) 2005; 169 Rottier (10.1111/j.1462-5822.2007.00951.x-BIB8) 1981; 40 Kuo (10.1111/j.1462-5822.2007.00951.x-BIB55) 2000; 74 Drosten (10.1111/j.1462-5822.2007.00951.x-BIB2) 2003; 348 Esclatine (10.1111/j.1462-5822.2007.00951.x-BIB52) 2004; 78 Harding (10.1111/j.1462-5822.2007.00951.x-BIB18) 1999; 397 Siddell (10.1111/j.1462-5822.2007.00951.x-BIB9) 1981; 142 Kedersha (10.1111/j.1462-5822.2007.00951.x-BIB21) 1999; 147 Scorsone (10.1111/j.1462-5822.2007.00951.x-BIB64) 1987; 262 Teixeira (10.1111/j.1462-5822.2007.00951.x-BIB29) 2005; 11 Smith (10.1111/j.1462-5822.2007.00951.x-BIB50) 2006; 80 Lai (10.1111/j.1462-5822.2007.00951.x-BIB31) 1981; 39 Grigull (10.1111/j.1462-5822.2007.00951.x-BIB47) 2004; 24 Hilton (10.1111/j.1462-5822.2007.00951.x-BIB10) 1986; 67 Lyles (10.1111/j.1462-5822.2007.00951.x-BIB1) 2000; 64 de Haro (10.1111/j.1462-5822.2007.00951.x-BIB16) 1996; 10 Woo (10.1111/j.1462-5822.2007.00951.x-BIB4) 2005; 79 Gilks (10.1111/j.1462-5822.2007.00951.x-BIB37) 2004; 15 McInerney (10.1111/j.1462-5822.2007.00951.x-BIB36) 2005; 16 Chan (10.1111/j.1462-5822.2007.00951.x-BIB51) 2006; 80 Banerjee (10.1111/j.1462-5822.2007.00951.x-BIB12) 2000; 74 de Haan (10.1111/j.1462-5822.2007.00951.x-BIB38) 2005; 79 Sawicki (10.1111/j.1462-5822.2007.00951.x-BIB6) 2005; 287 Keyse (10.1111/j.1462-5822.2007.00951.x-BIB40) 1992; 359 Scheuner (10.1111/j.1462-5822.2007.00951.x-BIB35) 2001; 7 Berlanga (10.1111/j.1462-5822.2007.00951.x-BIB17) 1999; 265
References_xml	– volume: 24 start-page: 5534 year: 2004 end-page: 5547 article-title: Genome‐wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors publication-title: Mol Cell Biol – volume: 8 start-page: 1489 year: 2002 end-page: 1501 article-title: The human LSm1–7 proteins colocalize with the mRNA‐degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci publication-title: RNA – volume: 279 start-page: 13792 year: 2004 end-page: 13799 article-title: Herp is dually regulated by both the endoplasmic reticulum stress‐specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways publication-title: J Biol Chem – volume: 39 start-page: 823 year: 1981 end-page: 834 article-title: Mouse hepatitis virus A59: mRNA structure and genetic localization of the sequence divergence from hepatotropic strain MHV‐3 publication-title: J Virol – volume: 4 start-page: 387 year: 2003 end-page: 393 article-title: Monitoring global messenger RNA changes in externally controlled microarray experiments publication-title: EMBO Rep – volume: 172 start-page: 803 year: 2006 end-page: 808 article-title: RNA granules publication-title: J Cell Biol – volume: 13 start-page: 1338 year: 2002 end-page: 1351 article-title: A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles publication-title: Mol Biol Cell – volume: 64 start-page: 709 year: 2000 end-page: 724 article-title: Cytopathogenesis and inhibition of host gene expression by RNA viruses publication-title: Microbiol Mol Biol Rev – volume: 397 start-page: 271 year: 1999 end-page: 274 article-title: Protein translation and folding are coupled by an endoplasmic‐reticulum‐resident kinase publication-title: Nature – volume: 278 start-page: 12085 year: 2003 end-page: 12093 article-title: Heterogeneity in control of mRNA stability by AU‐rich elements publication-title: J Biol Chem – volume: 77 start-page: 8801 year: 2003 end-page: 8811 article-title: The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex publication-title: J Virol – volume: 202 start-page: 621 year: 1994 end-page: 630 article-title: Coronavirus translational regulation: leader affects mRNA efficiency publication-title: Virology – volume: 331 start-page: 991 year: 2003 end-page: 1004 article-title: Unique and conserved features of genome and proteome of SARS‐coronavirus, an early split‐off from the coronavirus group 2 lineage publication-title: J Mol Biol – volume: 94 start-page: 352 year: 1979 end-page: 370 article-title: Pathogenic murine coronaviruses. I. Characterization of biological behavior and virus‐specific intracellular RNA of strongly neurotropic JHMV and weakly neurotropic A59V viruses publication-title: Virology – volume: 9 start-page: 1171 year: 2003 end-page: 1173 article-title: The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies publication-title: RNA – volume: 79 start-page: 884 year: 2005 end-page: 895 article-title: Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia publication-title: J Virol – volume: 58 start-page: 79 year: 1998 end-page: 125 article-title: Regulation of translational initiation during cellular responses to stress publication-title: Prog Nucleic Acid Res Mol Biol – volume: 16 start-page: 3753 year: 2005 end-page: 3763 article-title: Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation publication-title: Mol Biol Cell – volume: 11 start-page: 4241 year: 2000 end-page: 4257 article-title: Genomic expression programs in the response of yeast cells to environmental changes publication-title: Mol Biol Cell – volume: 15 start-page: 5383 year: 2004 end-page: 5398 article-title: Stress granule assembly is mediated by prion‐like aggregation of TIA‐1 publication-title: Mol Biol Cell – volume: 287 start-page: 31 year: 2005 end-page: 55 article-title: Coronavirus transcription: a perspective publication-title: Curr Top Microbiol Immunol – volume: 169 start-page: 871 year: 2005 end-page: 884 article-title: Stress granules and processing bodies are dynamically linked sites of mRNP remodeling publication-title: J Cell Biol – volume: 262 start-page: 14538 year: 1987 end-page: 14543 article-title: Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis publication-title: J Biol Chem – volume: 103 start-page: 12885 year: 2006 end-page: 12890 article-title: Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation publication-title: Proc Natl Acad Sci USA – volume: 76 start-page: 11989 year: 2002 end-page: 12000 article-title: Cell proteins TIA‐1 and TIAR interact with the 3′ stem‐loop of the West Nile virus complementary minus‐strand RNA and facilitate virus replication publication-title: J Virol – volume: 16 start-page: 13 year: 2005 end-page: 20 article-title: Translational control in virus‐infected cells: models for cellular stress responses publication-title: Semin Cell Dev Biol – volume: 78 start-page: 6048 year: 2004 end-page: 6054 article-title: Cleavage inhibition of the murine coronavirus spike protein by a furin‐like enzyme affects cell‐cell but not virus‐cell fusion publication-title: J Virol – volume: 21 start-page: 7971 year: 2001 end-page: 7980 article-title: Translation initiation control by heme‐regulated eukaryotic initiation factor 2 alpha kinase in erythroid cells under cytoplasmic stresses publication-title: Mol Cell Biol – volume: 7 start-page: 1165 year: 2001 end-page: 1176 article-title: Translational control is required for the unfolded protein response and glucose homeostasis publication-title: Mol Cell – volume: 265 start-page: 754 year: 1999 end-page: 762 article-title: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2 alpha kinase publication-title: Eur J Biochem – volume: 1058 start-page: 196 year: 2005 end-page: 204 article-title: Stability regulation of mRNA and the control of gene expression publication-title: Ann N Y Acad Sci – volume: 17 start-page: 1291 year: 1997 end-page: 1302 article-title: Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha publication-title: J Cereb Blood Flow Metab – start-page: 503 year: 2000 end-page: 527 – volume: 280 start-page: 16925 year: 2005 end-page: 16933 article-title: Heme‐regulated inhibitor kinase‐mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure publication-title: J Biol Chem – volume: 78 start-page: 8582 year: 2004 end-page: 8592 article-title: Herpes simplex virus 1 induces cytoplasmic accumulation of TIA‐1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU‐rich RNAs publication-title: J Virol – volume: 81 start-page: 416 year: 2007 end-page: 422 article-title: Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation publication-title: J Virol – volume: 7 start-page: 248 year: 2005 end-page: 259 article-title: Microarray and real‐time RT‐PCR analyses of differential human gene expression patterns induced by severe acute respiratory syndrome (SARS) coronavirus infection of Vero cells publication-title: Microbes Infect – volume: 10 start-page: 1378 year: 1996 end-page: 1387 article-title: The eIF‐2alpha kinases and the control of protein synthesis publication-title: FASEB J – volume: 342 start-page: 111 year: 1993 end-page: 116 article-title: Effects of mouse hepatitis virus infection on host cell metabolism publication-title: Adv Exp Med Biol – volume: 74 start-page: 4967 year: 2000 end-page: 4978 article-title: Assembly of the coronavirus envelope: homotypic interactions between the M proteins publication-title: J Virol – volume: 98 start-page: 5116 year: 2001 end-page: 5121 article-title: Significance analysis of microarrays applied to the ionizing radiation response publication-title: Proc Natl Acad Sci USA – volume: 12 start-page: 323 year: 2001 end-page: 337 article-title: Remodeling of yeast genome expression in response to environmental changes publication-title: Mol Biol Cell – volume: 87 start-page: 1961 year: 2006 end-page: 1975 article-title: Transcriptional profiling of acute cytopathic murine hepatitis virus infection in fibroblast‐like cells publication-title: J Gen Virol – volume: 67 start-page: 923 year: 1986 end-page: 932 article-title: Translational control in murine hepatitis virus infection publication-title: J Gen Virol – volume: 80 start-page: 2019 year: 2006 end-page: 2033 article-title: Reovirus induces and benefits from an integrated cellular stress response publication-title: J Virol – volume: 80 start-page: 9279 year: 2006 end-page: 9287 article-title: Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein publication-title: J Virol – volume: 74 start-page: 8793 year: 2000 end-page: 8802 article-title: RNase 1‐independent specific 28S rRNA cleavage in murine coronavirus‐infected cells publication-title: J Virol – volume: 30 start-page: e15 year: 2002 article-title: Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation publication-title: Nucleic Acids Res – volume: 165 start-page: 31 year: 2004 end-page: 40 article-title: Cytoplasmic foci are sites of mRNA decay in human cells publication-title: J Cell Biol – volume: 10 start-page: 368 year: 2004 end-page: 373 article-title: Identification of a new human coronavirus publication-title: Nat Med – volume: 7 start-page: 1261 year: 2005 end-page: 1266 article-title: A role for the P‐body component GW182 in microRNA function publication-title: Nat Cell Biol – volume: 11 start-page: 371 year: 2005 end-page: 382 article-title: Processing bodies require RNA for assembly and contain nontranslating mRNAs publication-title: RNA – volume: 74 start-page: 1393 year: 2000 end-page: 1406 article-title: Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier publication-title: J Virol – volume: 115 start-page: 3227 year: 2002 end-page: 3234 article-title: Stressful initiations publication-title: J Cell Sci – volume: 68 start-page: 6815 year: 1994 end-page: 6819 article-title: Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis publication-title: J Virol – volume: 28 start-page: 130 year: 2003 end-page: 136 article-title: Translation initiation and viral tricks publication-title: Trends Biochem Sci – volume: 359 start-page: 644 year: 1992 end-page: 647 article-title: Oxidative stress and heat shock induce a human gene encoding a protein‐tyrosine phosphatase publication-title: Nature – volume: 87 start-page: 1403 year: 2006 end-page: 1421 article-title: Nidovirus transcription: how to make sense…? publication-title: J Gen Virol – volume: 79 start-page: 12742 year: 2005 end-page: 12751 article-title: Coronaviruses as vectors: stability of foreign gene expression publication-title: J Virol – volume: 142 start-page: 193 year: 1981 end-page: 207 article-title: Intracellular protein synthesis and the translation of coronavirus JHM mRNA publication-title: Adv Exp Med Biol – volume: 348 start-page: 1967 year: 2003 end-page: 1976 article-title: Identification of a novel coronavirus in patients with severe acute respiratory syndrome publication-title: N Engl J Med – volume: 147 start-page: 1431 year: 1999 end-page: 1442 article-title: RNA‐binding proteins TIA‐1 and TIAR link the phosphorylation of eIF‐2 alpha to the assembly of mammalian stress granules publication-title: J Cell Biol – volume: 37 start-page: 182 year: 2005 end-page: 186 article-title: An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas publication-title: Nat Genet – volume: 40 start-page: 350 year: 1981 end-page: 357 article-title: Viral protein synthesis in mouse hepatitis virus strain A59‐infected cells: effect of tunicamycin publication-title: J Virol – volume: 76 start-page: 11989 year: 2002 ident: 10.1111/j.1462-5822.2007.00951.x-BIB53 article-title: Cell proteins TIA-1 and TIAR interact with the 3′ stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication publication-title: J Virol doi: 10.1128/JVI.76.23.11989-12000.2002 – volume: 1058 start-page: 196 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB32 article-title: Stability regulation of mRNA and the control of gene expression publication-title: Ann N Y Acad Sci doi: 10.1196/annals.1359.026 – volume: 165 start-page: 31 year: 2004 ident: 10.1111/j.1462-5822.2007.00951.x-BIB26 article-title: Cytoplasmic foci are sites of mRNA decay in human cells publication-title: J Cell Biol doi: 10.1083/jcb.200309008 – volume: 4 start-page: 387 year: 2003 ident: 10.1111/j.1462-5822.2007.00951.x-BIB59 article-title: Monitoring global messenger RNA changes in externally controlled microarray experiments publication-title: EMBO Rep doi: 10.1038/sj.embor.embor798 – volume: 67 start-page: 923 year: 1986 ident: 10.1111/j.1462-5822.2007.00951.x-BIB10 article-title: Translational control in murine hepatitis virus infection publication-title: J Gen Virol doi: 10.1099/0022-1317-67-5-923 – volume: 16 start-page: 13 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB49 article-title: Translational control in virus-infected cells: models for cellular stress responses publication-title: Semin Cell Dev Biol doi: 10.1016/j.semcdb.2004.11.011 – volume: 103 start-page: 12885 year: 2006 ident: 10.1111/j.1462-5822.2007.00951.x-BIB14 article-title: Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0603144103 – volume: 74 start-page: 8793 year: 2000 ident: 10.1111/j.1462-5822.2007.00951.x-BIB12 article-title: RNase 1-independent specific 28S rRNA cleavage in murine coronavirus-infected cells publication-title: J Virol doi: 10.1128/JVI.74.19.8793-8802.2000 – volume: 37 start-page: 182 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB58 article-title: An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas publication-title: Nat Genet doi: 10.1038/ng1502 – volume: 17 start-page: 1291 year: 1997 ident: 10.1111/j.1462-5822.2007.00951.x-BIB63 article-title: Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha publication-title: J Cereb Blood Flow Metab doi: 10.1097/00004647-199712000-00004 – volume: 142 start-page: 193 year: 1981 ident: 10.1111/j.1462-5822.2007.00951.x-BIB9 article-title: Intracellular protein synthesis and the in vitro translation of coronavirus JHM mRNA publication-title: Adv Exp Med Biol doi: 10.1007/978-1-4757-0456-3_17 – volume: 81 start-page: 416 year: 2007 ident: 10.1111/j.1462-5822.2007.00951.x-BIB48 article-title: Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation publication-title: J Virol doi: 10.1128/JVI.02336-05 – volume: 24 start-page: 5534 year: 2004 ident: 10.1111/j.1462-5822.2007.00951.x-BIB47 article-title: Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors publication-title: Mol Cell Biol doi: 10.1128/MCB.24.12.5534-5547.2004 – volume: 64 start-page: 709 year: 2000 ident: 10.1111/j.1462-5822.2007.00951.x-BIB1 article-title: Cytopathogenesis and inhibition of host gene expression by RNA viruses publication-title: Microbiol Mol Biol Rev doi: 10.1128/MMBR.64.4.709-724.2000 – volume: 15 start-page: 5383 year: 2004 ident: 10.1111/j.1462-5822.2007.00951.x-BIB37 article-title: Stress granule assembly is mediated by prion-like aggregation of TIA-1 publication-title: Mol Biol Cell doi: 10.1091/mbc.e04-08-0715 – volume: 79 start-page: 884 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB4 article-title: Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia publication-title: J Virol doi: 10.1128/JVI.79.2.884-895.2005 – volume: 30 start-page: e15 year: 2002 ident: 10.1111/j.1462-5822.2007.00951.x-BIB60 article-title: Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation publication-title: Nucleic Acids Res doi: 10.1093/nar/30.4.e15 – volume: 9 start-page: 1171 year: 2003 ident: 10.1111/j.1462-5822.2007.00951.x-BIB25 article-title: The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies publication-title: RNA doi: 10.1261/rna.5810203 – volume: 147 start-page: 1431 year: 1999 ident: 10.1111/j.1462-5822.2007.00951.x-BIB21 article-title: RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules publication-title: J Cell Biol doi: 10.1083/jcb.147.7.1431 – volume: 78 start-page: 8582 year: 2004 ident: 10.1111/j.1462-5822.2007.00951.x-BIB52 article-title: Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs publication-title: J Virol doi: 10.1128/JVI.78.16.8582-8592.2004 – volume: 287 start-page: 31 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB6 article-title: Coronavirus transcription: a perspective publication-title: Curr Top Microbiol Immunol – volume: 80 start-page: 9279 year: 2006 ident: 10.1111/j.1462-5822.2007.00951.x-BIB51 article-title: Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein publication-title: J Virol doi: 10.1128/JVI.00659-06 – volume: 172 start-page: 803 year: 2006 ident: 10.1111/j.1462-5822.2007.00951.x-BIB23 article-title: RNA granules publication-title: J Cell Biol doi: 10.1083/jcb.200512082 – volume: 279 start-page: 13792 year: 2004 ident: 10.1111/j.1462-5822.2007.00951.x-BIB41 article-title: Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways publication-title: J Biol Chem doi: 10.1074/jbc.M313724200 – volume: 68 start-page: 6815 year: 1994 ident: 10.1111/j.1462-5822.2007.00951.x-BIB13 article-title: Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis publication-title: J Virol doi: 10.1128/JVI.68.10.6815-6819.1994 – volume: 16 start-page: 3753 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB36 article-title: Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation publication-title: Mol Biol Cell doi: 10.1091/mbc.e05-02-0124 – volume: 11 start-page: 371 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB29 article-title: Processing bodies require RNA for assembly and contain nontranslating mRNAs publication-title: RNA doi: 10.1261/rna.7258505 – volume: 74 start-page: 1393 year: 2000 ident: 10.1111/j.1462-5822.2007.00951.x-BIB55 article-title: Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier publication-title: J Virol doi: 10.1128/JVI.74.3.1393-1406.2000 – volume: 12 start-page: 323 year: 2001 ident: 10.1111/j.1462-5822.2007.00951.x-BIB46 article-title: Remodeling of yeast genome expression in response to environmental changes publication-title: Mol Biol Cell doi: 10.1091/mbc.12.2.323 – volume: 28 start-page: 130 year: 2003 ident: 10.1111/j.1462-5822.2007.00951.x-BIB39 article-title: Translation initiation and viral tricks publication-title: Trends Biochem Sci doi: 10.1016/S0968-0004(03)00029-X – volume: 265 start-page: 754 year: 1999 ident: 10.1111/j.1462-5822.2007.00951.x-BIB17 article-title: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2 alpha kinase publication-title: Eur J Biochem doi: 10.1046/j.1432-1327.1999.00780.x – volume: 202 start-page: 621 year: 1994 ident: 10.1111/j.1462-5822.2007.00951.x-BIB11 article-title: Coronavirus translational regulation: leader affects mRNA efficiency publication-title: Virology doi: 10.1006/viro.1994.1383 – volume: 94 start-page: 352 year: 1979 ident: 10.1111/j.1462-5822.2007.00951.x-BIB30 article-title: Pathogenic murine coronaviruses. I. Characterization of biological behavior in vitro and virus-specific intracellular RNA of strongly neurotropic JHMV and weakly neurotropic A59V viruses publication-title: Virology doi: 10.1016/0042-6822(79)90467-7 – volume: 58 start-page: 79 year: 1998 ident: 10.1111/j.1462-5822.2007.00951.x-BIB15 article-title: Regulation of translational initiation during cellular responses to stress publication-title: Prog Nucleic Acid Res Mol Biol doi: 10.1016/S0079-6603(08)60034-3 – volume: 78 start-page: 6048 year: 2004 ident: 10.1111/j.1462-5822.2007.00951.x-BIB62 article-title: Cleavage inhibition of the murine coronavirus spike protein by a furin-like enzyme affects cell-cell but not virus-cell fusion publication-title: J Virol doi: 10.1128/JVI.78.11.6048-6054.2004 – volume: 77 start-page: 8801 year: 2003 ident: 10.1111/j.1462-5822.2007.00951.x-BIB56 article-title: The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex publication-title: J Virol doi: 10.1128/JVI.77.16.8801-8811.2003 – volume: 74 start-page: 4967 year: 2000 ident: 10.1111/j.1462-5822.2007.00951.x-BIB57 article-title: Assembly of the coronavirus envelope: homotypic interactions between the M proteins publication-title: J Virol doi: 10.1128/JVI.74.11.4967-4978.2000 – volume: 262 start-page: 14538 year: 1987 ident: 10.1111/j.1462-5822.2007.00951.x-BIB64 article-title: Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)47829-5 – start-page: 503 volume-title: Translational Control of Gene Expression. year: 2000 ident: 10.1111/j.1462-5822.2007.00951.x-BIB19 – volume: 11 start-page: 4241 year: 2000 ident: 10.1111/j.1462-5822.2007.00951.x-BIB45 article-title: Genomic expression programs in the response of yeast cells to environmental changes publication-title: Mol Biol Cell doi: 10.1091/mbc.11.12.4241 – volume: 115 start-page: 3227 year: 2002 ident: 10.1111/j.1462-5822.2007.00951.x-BIB22 article-title: Stressful initiations publication-title: J Cell Sci doi: 10.1242/jcs.115.16.3227 – volume: 13 start-page: 1338 year: 2002 ident: 10.1111/j.1462-5822.2007.00951.x-BIB34 article-title: A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles publication-title: Mol Biol Cell doi: 10.1091/mbc.01-11-0544 – volume: 10 start-page: 368 year: 2004 ident: 10.1111/j.1462-5822.2007.00951.x-BIB3 article-title: Identification of a new human coronavirus publication-title: Nat Med doi: 10.1038/nm1024 – volume: 39 start-page: 823 year: 1981 ident: 10.1111/j.1462-5822.2007.00951.x-BIB31 article-title: Mouse hepatitis virus A59: mRNA structure and genetic localization of the sequence divergence from hepatotropic strain MHV-3 publication-title: J Virol doi: 10.1128/JVI.39.3.823-834.1981 – volume: 278 start-page: 12085 year: 2003 ident: 10.1111/j.1462-5822.2007.00951.x-BIB43 article-title: Heterogeneity in control of mRNA stability by AU-rich elements publication-title: J Biol Chem doi: 10.1074/jbc.M212992200 – volume: 79 start-page: 12742 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB38 article-title: Coronaviruses as vectors: stability of foreign gene expression publication-title: J Virol doi: 10.1128/JVI.79.20.12742-12751.2005 – volume: 7 start-page: 1261 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB27 article-title: A role for the P-body component GW182 in microRNA function publication-title: Nat Cell Biol doi: 10.1038/ncb1333 – volume: 80 start-page: 2019 year: 2006 ident: 10.1111/j.1462-5822.2007.00951.x-BIB50 article-title: Reovirus induces and benefits from an integrated cellular stress response publication-title: J Virol doi: 10.1128/JVI.80.4.2019-2033.2006 – volume: 169 start-page: 871 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB28 article-title: Stress granules and processing bodies are dynamically linked sites of mRNP remodeling publication-title: J Cell Biol doi: 10.1083/jcb.200502088 – volume: 331 start-page: 991 year: 2003 ident: 10.1111/j.1462-5822.2007.00951.x-BIB7 article-title: Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage publication-title: J Mol Biol doi: 10.1016/S0022-2836(03)00865-9 – volume: 8 start-page: 1489 year: 2002 ident: 10.1111/j.1462-5822.2007.00951.x-BIB24 article-title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci publication-title: RNA doi: 10.1017/S1355838202021726 – volume: 98 start-page: 5116 year: 2001 ident: 10.1111/j.1462-5822.2007.00951.x-BIB61 article-title: Significance analysis of microarrays applied to the ionizing radiation response publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.091062498 – volume: 10 start-page: 1378 year: 1996 ident: 10.1111/j.1462-5822.2007.00951.x-BIB16 article-title: The eIF-2alpha kinases and the control of protein synthesis publication-title: FASEB J doi: 10.1096/fasebj.10.12.8903508 – volume: 397 start-page: 271 year: 1999 ident: 10.1111/j.1462-5822.2007.00951.x-BIB18 article-title: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase publication-title: Nature doi: 10.1038/16729 – volume: 359 start-page: 644 year: 1992 ident: 10.1111/j.1462-5822.2007.00951.x-BIB40 article-title: Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase publication-title: Nature doi: 10.1038/359644a0 – volume: 21 start-page: 7971 year: 2001 ident: 10.1111/j.1462-5822.2007.00951.x-BIB20 article-title: Translation initiation control by heme-regulated eukaryotic initiation factor 2 alpha kinase in erythroid cells under cytoplasmic stresses publication-title: Mol Cell Biol doi: 10.1128/MCB.21.23.7971-7980.2001 – volume: 348 start-page: 1967 year: 2003 ident: 10.1111/j.1462-5822.2007.00951.x-BIB2 article-title: Identification of a novel coronavirus in patients with severe acute respiratory syndrome publication-title: N Engl J Med doi: 10.1056/NEJMoa030747 – volume: 342 start-page: 111 year: 1993 ident: 10.1111/j.1462-5822.2007.00951.x-BIB54 article-title: Effects of mouse hepatitis virus infection on host cell metabolism publication-title: Adv Exp Med Biol doi: 10.1007/978-1-4615-2996-5_18 – volume: 280 start-page: 16925 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB33 article-title: Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure publication-title: J Biol Chem doi: 10.1074/jbc.M412882200 – volume: 40 start-page: 350 year: 1981 ident: 10.1111/j.1462-5822.2007.00951.x-BIB8 article-title: Viral protein synthesis in mouse hepatitis virus strain A59-infected cells: effect of tunicamycin publication-title: J Virol doi: 10.1128/JVI.40.2.350-357.1981 – volume: 7 start-page: 1165 year: 2001 ident: 10.1111/j.1462-5822.2007.00951.x-BIB35 article-title: Translational control is required for the unfolded protein response and in vivo glucose homeostasis publication-title: Mol Cell doi: 10.1016/S1097-2765(01)00265-9 – volume: 87 start-page: 1403 year: 2006 ident: 10.1111/j.1462-5822.2007.00951.x-BIB5 article-title: Nidovirus transcription: how to make sense…? publication-title: J Gen Virol doi: 10.1099/vir.0.81611-0 – volume: 7 start-page: 248 year: 2005 ident: 10.1111/j.1462-5822.2007.00951.x-BIB44 article-title: Microarray and real-time RT-PCR analyses of differential human gene expression patterns induced by severe acute respiratory syndrome (SARS) coronavirus infection of Vero cells publication-title: Microbes Infect doi: 10.1016/j.micinf.2004.11.004 – volume: 87 start-page: 1961 year: 2006 ident: 10.1111/j.1462-5822.2007.00951.x-BIB42 article-title: Transcriptional profiling of acute cytopathic murine hepatitis virus infection in fibroblast-like cells publication-title: J Gen Virol doi: 10.1099/vir.0.81756-0
SSID	ssj0016711
Score	2.2322736
Snippet	Summary Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we... Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed...
SourceID	pubmedcentral proquest pubmed crossref wiley
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	2218
SubjectTerms	Animals Cells, Cultured Coronavirus Coronavirus Infections - metabolism COVID-19 Cytoplasmic Granules - metabolism Decay Eukaryotic Initiation Factor-2 - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - virology Hepatitis Hepatitis, Viral, Animal - metabolism Humans Mice Molecular Sequence Data Murine hepatitis virus - genetics Murine hepatitis virus - physiology Oligonucleotide Array Sequence Analysis Original Protein Biosynthesis Protein synthesis RNA Stability RNA, Messenger - metabolism Transcription, Genetic Virus Replication
Title	Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies
URI	https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1462-5822.2007.00951.x https://www.ncbi.nlm.nih.gov/pubmed/17490409 https://www.proquest.com/docview/203584398 https://www.proquest.com/docview/20467008 https://www.proquest.com/docview/68166807 https://pubmed.ncbi.nlm.nih.gov/PMC7162177
Volume	9
WOSCitedRecordID	wos000248666600011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVWIB databaseName: Wiley Online Library customDbUrl: eissn: 1462-5822 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0016711 issn: 1462-5814 databaseCode: DRFUL dateStart: 19990101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 1462-5822 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0016711 issn: 1462-5814 databaseCode: WIN dateStart: 19990101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9QwDI9ggMQL37Db4MgDjxQ1ado0j9PYiUnbCU1M3FvVfO1OOtrpep22f4a_dXbbK3RDaEK8VWpsNakdO7H9MyEfQmGYT7UFz035QHAbBtorFfAoF1xKx3PT4Mweyek0nc3U1y7_CWthWnyI_sINNaPZr1HBc13dVHI4SIGF2yARgrfwCf1JJhod_X447QMKiWxa8XYkTAyTev7IaGipbrmft7Mof_duG_M0efo_J_aMPOmcVLrXStVzcs8VL8ijtm3l1Uvy87isK0fnDrOx14uKGoRByC8Wq7qiK9dHxCmc90FyKoqVJHSNVnHZ3T3Sal6vS-9pXlj642S6R60z-dVHivfCwK-Aj15gg2PaV1fS0tO2soWeAat6CYyR-rwtdQATTHWJOZGvyOnk4Nv-l6Dr8xCYmCsWGHD7uLYhM9qJ2KcpY05wo5SXiRGOScOUtaGRkolYSynjPIFTKdepFUJZFr0mW0VZuG1CE9iAtVQIauaE16FmEXBKYsOtD5X3IyI3_zQzHQg69uJYZoPDEM9w9bFFJ0bnYfWzyxFhPeV5CwRyB5rdjdhk3dZQwYAInL5IpSPyvn8LOo2Bmrxw8ANhiMDqqb-MSDDcm4ZyRN60Qvjrm6RQsDErmOlAPPsBiCc-fFMs5g2uOIKJMQk840Y87zzNbP_4EB52_pFulzxuL8wxce8t2VqvaveOPDQXIMCrMbkvZ-mYPPh8Mjk9GjdKfQ36E0tN
linkProvider	Wiley-Blackwell
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdQB2IvfMPKgPmBR4Jix4njx2lQbaKt0LRJe4viL1qpJFPTTOyf4W_lLkkDYQhNiLdI8Z1i58539t39jpC3oTDMp9qC56Z8ILgNA-2VCniUCy6l47lpcGancj5PLy7U564dENbCtPgQ_YUbakazX6OC44X071oOJykwcVsoQnAX3oNDuSNAquIR2flwOjmf9kGFRDbteDsqJoaJPX_kNbRWN1zQm5mUv3q4jYmaPPyvk3tEHnSeKj1sResxueOKJ-Re27vy-in5PivrytGFw5TszbKiBrEQ8qvluq7o2vVhcQqHfhCfimI5Cd2gaVx1F5C0WtSb0nuaF5Z-PZ0fUutMfv2O4uUw8Cvgq5fY5Zj2JZa09LQtb6FfgFW9AsZIfdnWO4AdprrExMhn5Hzy8ezoOOiaPQQm5ooFBnw_rm3IjHYi9mnKmBPcKOVlYoRj0jBlbWikZCLWUso4T-BoynVqhVCWRc_JqCgLt0doAruwlgqRzZzwOtQsAk5JbLj1ofJ-TOT2p2amQ0LHhhyrbHAi4hmuPvbpxBA9rH72bUxYT3nZooHcgmZ_KzdZtz9UMCACzy9S6Zgc9G9BsTFakxcOfiAMEVhC9ZcRCcZ801COyYtWCn9-kxQKdmcFMx3IZz8AQcWHb4rlogEXR0QxJoFn3MjnraeZHc1O4OHlP9IdkPvHZ7NpNj2Zf9onu-0NOmbyvSKjzbp2r8ldcwXCvH7TafUPpxROEQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9QwDI_QBogXxue4DVgeeKSoSdOmeZw2TkzcTtPEpL1VzRd30q09Xa8T-2f4W7HbXqEMoQnxVqmx1aR27MT2z4S8C4VhPtUWPDflA8FtGGivVMCjXHApHc9NgzM7kdNpenmpzrp2QFgL0-JD9BduqBnNfo0K7pbW_67lcJICE7eBIgR34QM4lNsiVglo6fbx-fhi0gcVEtm04-2omBgm9vyR19Ba3XJBb2dS_urhNiZqvPNfJ_eEPO48VXrYitZTcs8Vz8iDtnflzXPy_bSsK0dnDlOy1_OKGsRCyK_nq7qiK9eHxSkc-kF8KorlJHSNpnHRXUDSalavS-9pXlh6dT49pNaZ_OY9xcth4FfAV8-xyzHtSyxp6Wlb3kK_Aqt6AYyRetnWO4AdprrExMgX5GL88cvRp6Br9hCYmCsWGPD9uLYhM9qJ2KcpY05wo5SXiRGOScOUtaGRkolYSynjPIGjKdepFUJZFr0kW0VZuFeEJrALa6kQ2cwJr0PNIuCUxIZbHyrvR0RufmpmOiR0bMixyAYnIp7h6mOfTgzRw-pn30aE9ZTLFg3kDjT7G7nJuv2hggEReH6RSkfkoH8Lio3Rmrxw8ANhiMASqr-MSDDmm4ZyRHZbKfz5TVIo2J0VzHQgn_0ABBUfvinmswZcHBHFmASecSOfd55mdnR6Ag97_0h3QB6eHY-zycn08z551F6gYyLfa7K1XtXuDblvrkGWV287pf4Bv4FNjA
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mouse+hepatitis+coronavirus+replication+induces+host+translational+shutoff+and+mRNA+decay%2C+with+concomitant+formation+of+stress+granules+and+processing+bodies&rft.jtitle=Cellular+microbiology&rft.au=Raaben%2C+Matthijs&rft.au=Groot+Koerkamp%2C+Marian+J+A&rft.au=Rottier%2C+Peter+J+M&rft.au=de+Haan%2C+Cornelis+A+M&rft.date=2007-09-01&rft.issn=1462-5814&rft.volume=9&rft.issue=9&rft.spage=2218&rft_id=info:doi/10.1111%2Fj.1462-5822.2007.00951.x&rft_id=info%3Apmid%2F17490409&rft.externalDocID=17490409
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1462-5814&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1462-5814&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1462-5814&client=summon