Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades

Mitogen-activated protein kinase (MAPK) cascades control cell fate decisions, such as proliferation, differentiation, and apoptosis by integrating and processing intra- and extracellular cues. However, similar MAPK kinetic profiles can be associated with opposing cellular decisions depending on cell...

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Veröffentlicht in:	Frontiers in physiology Jg. 3; S. 355
Hauptverfasser:	Fey, Dirk, Croucher, David R., Kolch, Walter, Kholodenko, Boris N.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Research Foundation 01.01.2012 Frontiers Media S.A
Schriftenreihe:	Research Topic: From structural to molecular systems biology: experimental and computational approaches to unravel mechanisms of kinase activity regulation in cancer and neurodegeneration
Schlagworte:	Akt (PKB bistability Dual specificity phosphatase (DUSP) dynamic model JNK Mitogen-Activated Protein Kinases Physiology dual specificity phosphatase Akt (PKB) bistability JNK mitogen-activated protein kinases dynamic model
ISSN:	1664-042X, 1664-042X
Online-Zugang:	Volltext
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