Hepatocyte-Derived Lipotoxic Extracellular Vesicle Sphingosine 1-Phosphate Induces Macrophage Chemotaxis

The pathophysiology of non-alcoholic steatohepatitis involves hepatocyte lipotoxicity due to excess saturated free fatty acids and concomitant proinflammatory macrophage effector responses. These include the infiltration of macrophages into hepatic cords in response to incompletely understood stimul...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 9; p. 2980
Main Authors:	Liao, Chieh-Yu, Song, Myeong Jun, Gao, Yandong, Mauer, Amy S., Revzin, Alexander, Malhi, Harmeet
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 19.12.2018
Subjects:	Animals Cell Line ceramide Chemotaxis - immunology Diet, Atherogenic - adverse effects Diet, Carbohydrate Loading - adverse effects Diet, High-Fat - adverse effects Disease Models, Animal Extracellular Vesicles - immunology Extracellular Vesicles - metabolism Gene Knockout Techniques Hepatocytes - drug effects Hepatocytes - immunology Hepatocytes - metabolism Humans Immunology Liver - cytology Liver - immunology Liver - pathology Lysophospholipids - immunology Lysophospholipids - metabolism Macrophages - immunology Male Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - immunology Non-alcoholic Fatty Liver Disease - pathology non-alcoholic steatohepatitis palmitic acid Palmitic Acid - pharmacology Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - immunology Receptors, Lysosphingolipid - metabolism sphingolipid signaling Sphingosine - analogs & derivatives Sphingosine - immunology Sphingosine - metabolism sphingosine kinase Sphingosine-1-Phosphate Receptors ceramide sphingolipid signaling palmitic acid sphingosine kinase non-alcoholic steatohepatitis
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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