Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions

Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%. The current knowledge about the vector-host-CCHFV interactions is...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology Vol. 7; p. 213
Main Authors: Papa, Anna, Tsergouli, Katerina, Tsioka, Katerina, Mirazimi, Ali
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media SA 26.05.2017
Frontiers Media S.A
Subjects:
Animals
Apoptosis
Arthropods
Crimean hemorrhagic fever
Crimean-Congo hemorrhagic fever virus
Cytokines - metabolism
Disease transmission
Exocrine glands
Fever
Genetic factors
Genomes
Glycoproteins
Hemolymph
Hemorrhagic Fever Virus, Crimean-Congo - pathogenicity
Hemorrhagic Fever Virus, Crimean-Congo - physiology
Hemorrhagic Fever, Crimean - transmission
Host-Pathogen Interactions - physiology
Humans
Immune response
Immune status
Infectious diseases
Inoculation
interactions
Ixodidae - immunology
Ixodidae - virology
Metabolomics
Metabolomics - methods
Microbiology
Midgut
Mutation
Pathogens
Proteins
Proteomics
Proteomics - methods
Reproductive organs
RNA polymerase
Salivary gland
Salivary Glands - virology
Symbiosis
tick
Ticks - immunology
Ticks - virology
Transcriptomics
Vectors
Viral infections
Virus Replication
Viruses
Asia
Europe
Africa
tick
immune response
humans
Crimean-Congo hemorrhagic fever virus
interactions
ISSN:2235-2988, 2235-2988
Online Access:Get full text
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Summary:Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%. The current knowledge about the vector-host-CCHFV interactions is very limited due to the high-level containment required for CCHFV studies. Among ticks, spp. are considered the most competent virus vectors. CCHFV evades the tick immune response, and following its replication in the lining of the tick's midgut, it is disseminated by the hemolymph in the salivary glands and reproductive organs. The introduction of salivary gland secretions into the host cells is the major route via which CCHFV enters the host. Following an initial amplification at the site of inoculation, the virus is spread to the target organs. Apoptosis is induced via both intrinsic and extrinsic pathways. Genetic factors and immune status of the host may affect the release of cytokines which play a major role in disease progression and outcome. It is expected that the use of new technology of metabolomics, transcriptomics and proteomics will lead to improved understanding of CCHFV-host interactions and identify potential targets for blocking the CCHFV transmission.
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Reviewed by: Kui Li, University of Tennessee Health Science Center, United States; Dan Drecktrah, University of Montana, United States
Edited by: Sarah Irène Bonnet, Institut National de la Recherche Agronomique (INRA), France
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2017.00213