HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5

We previously reported that the human HER2 gene encodes the intronic microRNA mir-4728, which is overexpressed together with its oncogenic host gene and may act independently of the HER2 receptor. More recently, we also reported that the oncogenic miR-21-5p is regulated by 3′ tailing and trimming by...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 35664
Main Authors:	Newie, Inga, Søkilde, Rolf, Persson, Helena, Jacomasso, Thiago, Gorbatenko, Andrej, Borg, Åke, de Hoon, Michiel, Pedersen, Stine F., Rovira, Carlos
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.10.2016 Nature Publishing Group
Subjects:	13 38/61 692/4028/67/395 692/53 Apoptosis Basic Medicine Breast cancer Breast Neoplasms - genetics Cancer and Oncology Cancer och onkologi Carcinogenesis Cell and Molecular Biology Cell cycle Cell growth Cell Line, Tumor Cell- och molekylärbiologi Clinical Medicine ErbB-2 protein Female Gene expression Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Kinases Klinisk medicin Medical and Health Sciences Medical research Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper MicroRNAs MicroRNAs - genetics miRNA multidisciplinary Polyadenine Polynucleotide adenylyltransferase Proteins Receptor, ErbB-2 - genetics Ribonuclease RNA Nucleotidyltransferases - metabolism Science Signal Transduction Transcription Tumors Up-Regulation
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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