Truncal Distribution of Fat Mass, Metabolic Profile and Hypothalamic-Pituitary Adrenal Axis Activity in Prepubertal Obese Children

To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children. TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity a...

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Veröffentlicht in:The Journal of pediatrics Jg. 150; H. 5; S. 535 - 539.e1
Hauptverfasser: Barat, Pascal, Gayard-Cros, Michelle, Andrew, Ruth, Corcuff, Jean-Benoît, Jouret, Béatrice, Barthe, Nicole, Perez, Paul, Germain, Christine, Tauber, Maïthé, Walker, Brian R., Mormede, Pierre, Duclos, Martine
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York, NY Mosby, Inc 2007
Elsevier
Schlagworte:
Adolescent
Biological and medical sciences
Body Fat Distribution
Child
Female
General aspects
Human health and pathology
Humans
Hypothalamo-Hypophyseal System - physiopathology
Life Sciences
Male
Medical sciences
Metabolic diseases
Obesity
Obesity - metabolism
Obesity - physiopathology
Pediatrics
Pituitary-Adrenal System - physiopathology
TDFM
THE
THF
QUICKI
DEXA
ACTH
DXM
HPA
CBG
HOMA
WBFM
BMI
Tetrahydrocortisone
Dexamethasone
Quantitative insulin sensitivity check index
Corticosteroid binding globulin
Body mass index
Hypothalamic-pituitary-adrenocortical
Truncal distribution of fat mass
Tetrahydrocortisol
Homeostasis model assessment of insulin resistance
Adrenocorticotropin hormone
Whole body fat mass
Dual energy-X ray absorptiometry
Human
Obesity
Pediatrics
Trunk
Adipose tissue
Hypothalamohypophysoadrenal axis
Nutrition disorder
Metabolism
Fat mass
Biological activity
Profile
Prepuberty
Distribution
Child
Nutritional status
HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
CORTISOL
ISSN:0022-3476, 1097-6833, 1097-6833
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Zusammenfassung:To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children. TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity and reactivity have been studied in 45 prepubertal obese children aged 6 to 11 years (girls) and 6 to 13 years (boys). After adjustment for whole body fat mass (%) (WBFM), TDFM correlated positively with insulin (r = 0.50, 95% CI [0.23; 0.70]) and homeostasis model assessment of insulin resistance (r = 0.52, 95% CI [0.25; 0.71]). When adjusted for WBFM, TDFM correlated positively with morning plasma cortisol (r = 0.38, 95% CI [0.15; 0.64]) in the total population. TDFM correlated negatively with the rise of salivary cortisol after a standard meal (r = −0.43, 95% CI [−0.71; −0.02]), obviously in girls. When adjusted for WBFM and TDFM, morning plasma cortisol correlated positively with total cholesterol (r = 0.41, 95% CI [0.11; 0.65]) and triglyceride (r = 0.44, 95% CI [0.14; 0.67]). The rise of salivary cortisol after a standard meal was negatively (r = −0.56, 95% CI [−0.85; −0.01]) and positively (r = 0.74, 95% CI [0.16; 0.94]) correlated with homeostasis model assessment of insulin resistance in boys and girls, respectively. Association exists in prepubertal obese children between TDFM and markers of HPA axis activity. These data suggest that HPA axis could be involved early in life in obesity associated with pejorative metabolic profile.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3476
1097-6833
1097-6833
DOI:10.1016/j.jpeds.2007.01.029