The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species

The fungal cell wall is located outside the plasma membrane and is the cell compartment that mediates all the relationships of the cell with the environment. It protects the contents of the cell, gives rigidity and defines the cellular structure. The cell wall is a skeleton with high plasticity that...

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Bibliographic Details
Published in:Frontiers in microbiology Vol. 10; p. 2993
Main Authors: Garcia-Rubio, Rocio, de Oliveira, Haroldo C., Rivera, Johanna, Trevijano-Contador, Nuria
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 09.01.2020
Subjects:
Aspergillus
Candida
cell wall
composition
Cryptococcus
Microbiology
synthesis
synthesis
Cryptococcus
Aspergillus
cell wall
composition
Candida
ISSN:1664-302X, 1664-302X
Online Access:Get full text
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Summary:The fungal cell wall is located outside the plasma membrane and is the cell compartment that mediates all the relationships of the cell with the environment. It protects the contents of the cell, gives rigidity and defines the cellular structure. The cell wall is a skeleton with high plasticity that protects the cell from different stresses, among which osmotic changes stand out. The cell wall allows interaction with the external environment since some of its proteins are adhesins and receptors. Since, some components have a high immunogenic capacity, certain wall components can drive the host's immune response to promote fungus growth and dissemination. The cell wall is a characteristic structure of fungi and is composed mainly of glucans, chitin and glycoproteins. As the components of the fungal cell wall are not present in humans, this structure is an excellent target for antifungal therapy. In this article, we review recent data on the composition and synthesis, influence of the components of the cell wall in fungi-host interaction and the role as a target for the next generation of antifungal drugs in yeasts ( and ) and filamentous fungi ( ).
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These authors have contributed equally to this work
This article was submitted to Fungi and Their Interactions, a section of the journal Frontiers in Microbiology
Edited by: Gustavo Alexis Niño-Vega, University of Guanajuato, Mexico
Reviewed by: Teresa Gonçalves, University of Coimbra, Portugal; Rebecca Anne Hall, University of Birmingham, United Kingdom
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2019.02993