Biomarkers of Platelet Activation and Their Prognostic Value in Patients With Sepsis-Associated Disseminated Intravascular Coagulopathy

Sepsis-associated disseminated intravascular coagulation (DIC) is related to marked hemostatic changes such as transient thrombocytopenia secondary to the endogenous activation and consumption of platelets. This study measured markers of platelet function in 103 adult ICU patients with clinically es...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis Vol. 27; p. 1076029620943300
Main Authors: Wegrzyn, Gracelene, Walborn, Amanda, Rondina, Matthew, Fareed, Jawed, Hoppensteadt, Debra
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 2021
SAGE PUBLICATIONS, INC
SAGE Publishing
Subjects:
Adult
Aged
Biomarkers
Biomarkers - blood
Blood Platelets - metabolism
Case-Control Studies
CD40 Ligand - blood
Disseminated Intravascular Coagulation - blood
Disseminated Intravascular Coagulation - diagnosis
Disseminated Intravascular Coagulation - etiology
Disseminated Intravascular Coagulation - mortality
Female
Humans
Male
Middle Aged
Original
Platelet Activation
Platelet Factor 4 - blood
Predictive Value of Tests
Prognosis
Risk Factors
Sepsis
Sepsis - blood
Sepsis - complications
Sepsis - diagnosis
Sepsis - mortality
Severity of Illness Index
Thromboplastin - metabolism
Young Adult
disseminated intravascular coagulation
biomarkers
platelets
sepsis
ISSN:1076-0296, 1938-2723, 1938-2723
Online Access:Get full text
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Summary:Sepsis-associated disseminated intravascular coagulation (DIC) is related to marked hemostatic changes such as transient thrombocytopenia secondary to the endogenous activation and consumption of platelets. This study measured markers of platelet function in 103 adult ICU patients with clinically established sepsis-associated DIC to determine the biomarker association with disease severity. Patients were categorized as having no DIC, nonovert DIC, or overt DIC using the International Society of Thrombosis and Hemostasis scoring system. Plasma levels of CD40L, platelet factor 4 (PF4), platelet-derived microparticles, and microparticle-associated tissue factor were quantified. Markers of platelet activation were significantly elevated in patients with DIC compared to healthy individuals. This increase was independent of platelet count. Levels of PF4 differed based on the severity of DIC and differentiated nonsurvivors and survivors. These findings suggest that the markers of platelet activation in DIC may not be regulated by the number of circulating platelets and may be independent of the factors leading to their consumption.
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ISSN:1076-0296
1938-2723
1938-2723
DOI:10.1177/1076029620943300