Therapeutic Interventions for Frail Elderly Patients: Part I. Published Randomized Trials

The body of literature for frailty as a prognostic marker continues to grow, yet the evidence for frailty as a therapeutic target is less well defined. In the setting of cardiovascular disease, the prevalence of frailty is elevated and its impact on mortality and major morbidity is substantial. Ther...

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Bibliographic Details
Published in:Progress in cardiovascular diseases Vol. 57; no. 2; pp. 134 - 143
Main Authors: Bibas, Lior, Levi, Michael, Bendayan, Melissa, Mullie, Louis, Forman, Daniel E., Afilalo, Jonathan
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.09.2014
Subjects:
Activities of Daily Living
Aged
Cardiovascular
Exercise Therapy - methods
Frail Elderly
Frailty
Humans
Randomized clinical trials
Randomized Controlled Trials as Topic
Sarcopenia
CVD
Sarcopenia
RCT
Randomized clinical trials
PPT
Frailty
SPPB
cardiovascular disease
physical performance test
randomized clinical trial
short physical performance battery
ISSN:0033-0620, 1873-1740, 1532-8643, 1873-1740
Online Access:Get full text
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Summary:The body of literature for frailty as a prognostic marker continues to grow, yet the evidence for frailty as a therapeutic target is less well defined. In the setting of cardiovascular disease, the prevalence of frailty is elevated and its impact on mortality and major morbidity is substantial. Therapeutic interventions aimed at improving frailty may impart gains in functional status and survival. Randomized clinical trials that tested one or more therapeutic interventions in a population of frail older adults were reviewed. The interventions studied were exercise training in 13 trials, nutritional supplementation in 4 trials, combined exercise plus nutritional supplementation in 7 trials, pharmaceutical agents in 8 trials, multi-dimensional programs in 5 trials, and home-based services in 1 trial. The main findings of these trials are explored along with a discussion of their relative merits and limitations.
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ISSN:0033-0620
1873-1740
1532-8643
1873-1740
DOI:10.1016/j.pcad.2014.07.004