Translocator protein ligand, YL-IPA08, attenuates lipopolysaccharide-induced depression-like behavior by promoting neural regeneration

Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. Mice wer...

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Veröffentlicht in:Neural regeneration research Jg. 13; H. 11; S. 1937 - 1944
Hauptverfasser: Zhang, Xiao-Ying, Zhang, Li-Ming, Mi, Wei-Dong, Li, Yun-Feng
Format: Journal Article
Sprache:Englisch
Veröffentlicht: India Medknow Publications and Media Pvt. Ltd 01.11.2018
Medknow Publications & Media Pvt. Ltd
Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China%Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China%State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China
Medknow Publications & Media Pvt Ltd
Schlagworte:
Analysis
Behavior
Brain
Depression, Mental
Inflammation
Laboratory animals
Ligands
Ligands (Biochemistry)
Lipopolysaccharides
Medical research
Mental depression
Mice
Nervous system
Neurogenesis
Regeneration
Beijing China
United States > US
China
dentate gyrus
neural regeneration
translocator protein
hippocampus
neuroinflammation
nerve regeneration
depression
lipopolysaccharide
YL-IPA08
ISSN:1673-5374, 1876-7958
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Abstract Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. Mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior. A mouse model was then established by intraventricular injection of 100 ng lipopolysaccharide. On days 16-24 after model establishment, mice were intragastrically administered 3 mg/kg YL-IPA08 daily. Immunohistochemistry was used to determine BrdU and NeuN expression in the hippocampus. YL-IPA08 effectively reversed the depression-like behavior of lipopolysaccharide-treated mice, restored body mass, increased the number of BrdU-positive cells, and the number and proportion of BrdU and NeuN double-positive cells. These findings indicate that YL-IPA08 can attenuate lipopolysaccharide-induced depression-like behavior in mice by promoting the formation of hippocampal neurons.
AbstractList Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. Mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior. A mouse model was then established by intraventricular injection of 100 ng lipopolysaccharide. On days 16–24 after model establishment, mice were intragastrically administered 3 mg/kg YL-IPA08 daily. Immunohistochemistry was used to determine BrdU and NeuN expression in the hippocampus. YL-IPA08 effectively reversed the depression-like behavior of lipopolysaccharide-treated mice, restored body mass, increased the number of BrdU-positive cells, and the number and proportion of BrdU and NeuN double-positive cells. These findings indicate that YL-IPA08 can attenuate lipopolysaccharide-induced depression-like behavior in mice by promoting the formation of hippocampal neurons.
Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. Mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior. A mouse model was then established by intraventricular injection of 100 ng lipopolysaccharide. On days 16-24 after model establishment, mice were intragastrically administered 3 mg/kg YL-IPA08 daily. Immunohistochemistry was used to determine BrdU and NeuN expression in the hippocampus. YL-IPA08 effectively reversed the depression-like behavior of lipopolysaccharide-treated mice, restored body mass, increased the number of BrdU-positive cells, and the number and proportion of BrdU and NeuN double-positive cells. These findings indicate that YL-IPA08 can attenuate lipopolysaccharide-induced depression-like behavior in mice by promoting the formation of hippocampal neurons.Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. Mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior. A mouse model was then established by intraventricular injection of 100 ng lipopolysaccharide. On days 16-24 after model establishment, mice were intragastrically administered 3 mg/kg YL-IPA08 daily. Immunohistochemistry was used to determine BrdU and NeuN expression in the hippocampus. YL-IPA08 effectively reversed the depression-like behavior of lipopolysaccharide-treated mice, restored body mass, increased the number of BrdU-positive cells, and the number and proportion of BrdU and NeuN double-positive cells. These findings indicate that YL-IPA08 can attenuate lipopolysaccharide-induced depression-like behavior in mice by promoting the formation of hippocampal neurons.
Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mecha-nism of action. Mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior. A mouse model was then established by intraventricular injection of 100 ng lipopolysaccharide. On days 16–24 after model establishment, mice were intragastrically administered 3 mg/kg YL-IPA08 daily. Immunohistochemistry was used to determine BrdU and NeuN expression in the hippocampus. YL-IPA08 effec-tively reversed the depression-like behavior of lipopolysaccharide-treated mice, restored body mass, increased the number of BrdU-positive cells, and the number and proportion of BrdU and NeuN double-positive cells. These findings indicate that YL-IPA08 can attenuate lipo-polysaccharide-induced depression-like behavior in mice by promoting the formation of hippocampal neurons.
Audience Academic
Author Mi, Wei-Dong
Zhang, Xiao-Ying
Li, Yun-Feng
Zhang, Li-Ming
AuthorAffiliation Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China;State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China%Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China%State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30233067$$D View this record in MEDLINE/PubMed
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Issue 11
Keywords dentate gyrus
neural regeneration
translocator protein
hippocampus
neuroinflammation
nerve regeneration
depression
lipopolysaccharide
YL-IPA08
Language English
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Author contributions: XYZ conceived the study, carried out the study execution and data analysis and contributed to the manuscript draft. LMZ participated in the study design, the construction of recombinant lentiviruses and the draft of manuscript. WDM and YFL contributed to the study design, data analysis and manuscript revision. All authors approved the final version of this paper.
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Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China
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Snippet Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator...
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StartPage 1937
SubjectTerms Analysis
Behavior
Brain
Depression, Mental
Inflammation
Laboratory animals
Ligands
Ligands (Biochemistry)
Lipopolysaccharides
Medical research
Mental depression
Mice
Nervous system
Neurogenesis
Regeneration
Title Translocator protein ligand, YL-IPA08, attenuates lipopolysaccharide-induced depression-like behavior by promoting neural regeneration
URI https://www.ncbi.nlm.nih.gov/pubmed/30233067
https://www.proquest.com/docview/2382143450
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https://d.wanfangdata.com.cn/periodical/zgsjzsyj-e201811015
https://pubmed.ncbi.nlm.nih.gov/PMC6183040
Volume 13
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