Multidrug-Resistant Bacterial Infections in Geriatric Hospitalized Patients before and after the COVID-19 Outbreak: Results from a Retrospective Observational Study in Two Geriatric Wards

The impact of the COVID-19 pandemic on multidrug-resistant (MDR) bacteria is unknown. The purpose of this study was to assess prevalence, etiology, and association with mortality of MDR bacteria in older adult patients before and after the first peak of the COVID-19 pandemic in Italy. An observation...

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Vydané v:Antibiotics (Basel) Ročník 10; číslo 1; s. 95
Hlavní autori: Gasperini, Beatrice, Cherubini, Antonio, Lucarelli, Moira, Espinosa, Emma, Prospero, Emilia
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 01.01.2021
MDPI
Predmet:
Activities of daily living
Antibiotics
Antimicrobial agents
Bacteria
Bacterial diseases
Bacterial infections
Coliforms
Coronaviruses
COVID-19
Disinfection & disinfectants
E coli
Etiology
Geriatrics
Hospitalization
Infections
Length of stay
Mortality
Multidrug resistance
multidrug-resistant bacteria
Observational studies
older adults
Older people
Pandemics
Public health
Severe acute respiratory syndrome coronavirus 2
Staphylococcus
Urinary tract diseases
Urinary tract infections
Urine
Urogenital system
Viral diseases
COVID-19
multidrug-resistant bacteria
older adults
hospitalization
Staphylococcus
ISSN:2079-6382, 2079-6382
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Shrnutí:The impact of the COVID-19 pandemic on multidrug-resistant (MDR) bacteria is unknown. The purpose of this study was to assess prevalence, etiology, and association with mortality of MDR bacteria in older adult patients before and after the first peak of the COVID-19 pandemic in Italy. An observational retrospective study was conducted in two geriatric wards of the Azienda Ospedaliera Ospedali Riuniti Marche Nord, Fano, and of the INRCA, IRCCS, Ancona, in the Marche Region, Italy, from December 2019 to February 2020 and from May to July 2020. A total of 73 patients (mean age 87.4 ± 5.9, 27.4% men) and 83 cultures (36 pre-COVID-19 and 47 post-COVID-19) were considered. Overall, 46 cultures (55.4%) reported MDR bacteria (50% in pre- and 59.6% in post-COVID-19 period, p = 0.384). MDR bacteria in bloodstream significantly increased in post-COVID-19 period (68.8% vs. 40.0% p = 0.038) and MDR bacteria in urine did not change (51.6 vs. 54.8%, p = 0.799). Escherichia coli was the main MDR bacterium in pre-COVID-19, p = 0.082 and post-COVID-19, p = 0.026. Among patients with MDR infection, in-hospital mortality was 37.5% and 68.8% in pre- and post-COVID-19, respectively (p = 0.104), and mortality at 30 days was higher in post-COVID-19 period (78.9% vs. 27.3%, p = 0.012). An increased number of MDR bacteria in bloodstream and mortality after MDR infection have been observed in the post-COVID-19 period.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics10010095