Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion

Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive system, or cells of the hematopoietic system. Throu...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS Vol. 82; no. 1; pp. 312 - 20
Main Authors: Ebnet, Klaus, Aurrand-Lions, Michel
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 13.08.2025
Springer Nature B.V
Springer
Subjects:
Adhesion
Amino acids
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell adhesion
Cell adhesion & migration
Cell Adhesion - physiology
Cell adhesion molecules
Cell Adhesion Molecules - chemistry
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - metabolism
Cell Biology
Cell migration
Cell Movement
Cell Polarity
Cell-Cell contacts
Crystallography
Genes
Glial cells
Hematopoietic system
Humans
JAM-C
Junctional adhesion molecules
Kinases
Life Sciences
Localization
Migration
Myelin
Neuronal-glial interactions
Phosphorylation
Proteins
Reproductive system
Review
Sheaths
Cell Polarity
Tight junctions
Migration
Cell adhesion
Cell-Cell contacts
JAM-C
Junctional adhesion molecules
ISSN:1420-9071, 1420-682X, 1420-9071
Online Access:Get full text
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Summary:Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive system, or cells of the hematopoietic system. Through trans-homophilic as well as trans-heterophilic interactions with the JAM family member JAM-B and with members of the integrin family JAM-C regulates diverse processes including epithelial barrier formation, leukocyte– endothelial interactions and transendothelial migration, neuronal cell migration along glial fibers, myelin sheath integrity, and germ cell migration. In this article, we review the biological activities of JAM-C, including its basic organization, its extracellular and intracellular interaction partners, and its diverse physiological functions.
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ISSN:1420-9071
1420-682X
1420-9071
DOI:10.1007/s00018-025-05829-z