Rift Valley Fever Virus Primes Immune Responses in Aedes aegypti Cells

The ongoing global emergence of arthropod-borne (arbo) viruses has accelerated research into the interactions of these viruses with the immune systems of their vectors. Only limited information exists on how bunyaviruses, such as Rift Valley fever virus (RVFV), are sensed by mosquito immunity or esc...

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Vydané v:Pathogens (Basel) Ročník 12; číslo 4; s. 563
Hlavní autori: Laureti, Mathilde, Lee, Rui-Xue, Bennett, Amelia, Wilson, Lucas Aladar, Sy, Victoria Elena, Kohl, Alain, Dietrich, Isabelle
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 06.04.2023
MDPI
Predmet:
Aedes aegypti
Aquatic insects
Arthropods
Bacteria
cell lines
Coccidioidomycosis
Dengue fever
Disease control
disease prevention
Economic importance
Gene expression
Gram-positive bacteria
humans
immune priming
Immune response
Immune system
Immunity
Infections
Kinases
mosquito immunity
Mosquitoes
Orthobunyavirus
Pathogens
Pattern recognition
Pattern recognition receptors
Penicillin
Peptides
Phosphorylation
Priming
Proteins
Public health
Replication
Rift Valley fever
Rift Valley fever phlebovirus
Rift Valley fever virus
RNA interference
RNA-mediated interference
Vector-borne diseases
Vectors
Viral diseases
Viral infections
virus replication
Viruses
United Kingdom > UK
immune priming
Rift Valley fever virus
mosquito immunity
ISSN:2076-0817, 2076-0817
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Shrnutí:The ongoing global emergence of arthropod-borne (arbo) viruses has accelerated research into the interactions of these viruses with the immune systems of their vectors. Only limited information exists on how bunyaviruses, such as Rift Valley fever virus (RVFV), are sensed by mosquito immunity or escape detection. RVFV is a zoonotic phlebovirus (Bunyavirales; Phenuiviridae) of veterinary and human public health and economic importance. We have shown that the infection of mosquitoes with RVFV triggers the activation of RNA interference pathways, which moderately restrict viral replication. Here, we aimed to better understand the interactions between RVFV and other vector immune signaling pathways that might influence RVFV replication and transmission. For this, we used the immunocompetent Aedes aegypti Aag2 cell line as a model. We found that bacteria-induced immune responses restricted RVFV replication. However, virus infection alone did not alter the gene expression levels of immune effectors. Instead, it resulted in the marked enhancement of immune responses to subsequent bacterial stimulation. The gene expression levels of several mosquito immune pattern recognition receptors were altered by RVFV infection, which may contribute to this immune priming. Our findings imply that there is a complex interplay between RVFV and mosquito immunity that could be targeted in disease prevention strategies.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens12040563